Korean J Anesthesiol.  2013 Feb;64(2):112-116. 10.4097/kjae.2013.64.2.112.

Comparison of hepatic and renal function between inhalation anesthesia with sevoflurane and remifentanil and total intravenous anesthesia with propofol and remifentanil for thyroidectomy

• Kim JW
• Kim JD
• Yu SB
• Ryu SJ

• KMID: 1798222
• DOI: http://doi.org/10.4097/kjae.2013.64.2.112

Abstract

BACKGROUND
Inhalation anesthetics are an important factor for postoperative hepatic and renal dysfunction. In this regard, TIVA can reduce the risk of hepatic and renal dysfunction inherited to inhalation anesthetics. The present study was conducted to determine whether hepatic and renal functions differ after anesthesia with sevoflurane and propofol.
METHODS
Two hundred patients, ASA physical status class I, II, scheduled for an elective thyroidectomy were randomly divided into two groups. Anesthesia was maintained with sevoflurane 1-2% and remifentanil in the sevoflurane group (Group S) and propofol 2-5 ug/ml and remifentanil 2-5 ng/ml at the effect site, using a target controlled infusion (TCI) pump in the TIVA group (Group T) to maintain BIS of 40-60. To evaluate the hepatic and renal function, aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN) and creatinine were tested at preoperation (baseline), postoperative 1 day and 3 days.
RESULTS
AST was increased at postoperative 1 day and 3 days, compared with that of the preoperation in Group S, and postoperative 1 day in Group T, but the values were within its normal limit. ALT was not changed after anesthesia in both groups. BUN was increased at postoperative 1 day, compared with that of the preoperation in Group S, but the value was within its normal limit. Creatinine was not changed after anesthesia in both groups.
CONCLUSIONS
The changes of hepatic and renal function after inhalation anesthesia with sevoflurane and TIVA with propofol and remifentanil for thyroidectomy were clinically insignificant, and there was no difference between the two methods.

Keyword

Alanine aminotransferase; Aspartate aminotransferase; Blood Urea Nitrogen (BUN); Creatinine; Inhalation anesthesia; Total intravenous anesthesia

MeSH Terms

Alanine Transaminase
Anesthesia
Anesthesia, Inhalation
Anesthesia, Intravenous
Anesthetics, Inhalation
Aspartate Aminotransferases
Blood Urea Nitrogen
Creatinine
Humans
Inhalation
Methyl Ethers
Piperidines
Propofol
Thyroidectomy
Alanine Transaminase
Anesthetics, Inhalation
Aspartate Aminotransferases
Creatinine
Methyl Ethers
Piperidines
Propofol