Korean J Anesthesiol.  2008 Feb;54(2):134-138. 10.4097/kjae.2008.54.2.134.

The Effects of Propofol-remifentanil Total Intravenous Anesthesia on Platelet Function

• Son SC
• Lee WH
• Lee JH
• Lee JH
• Cho HY
• Shin YS

• KMID: 2244013
• DOI: http://doi.org/10.4097/kjae.2008.54.2.134

Abstract

BACKGROUND: The majority of anesthetic agents, including inhalation anesthetics, inhibit platelet function, but the effect of propofol on platelets is controversial. This study was designed to compare the effects of propofol-remifentanil total intravenous anesthesia and sevoflurane inhalation anesthesia on platelet function.
METHODS
Patients undergoing major hip surgery were divided into two groups: inhalation anesthesia with sevoflurane or total intravenous anesthesia with propofol and remifentanil. Hemoglobin, hematocrit, platelet count, prothrombin time, activated partial thromboplastin time, and platelet aggregation were measured 5 minutes before induction, the first hour intra-operatively, and the first hour postoperatively.
RESULTS
Total intravenous anesthesia with propofol and remifentanil significantly diminished collagen-induced platelet aggregation values intraoperatively compared with preoperative values. Also, intraoperative collagen- and adenosine diphosphate (ADP)-induced platelet aggregation was significantly lower in anesthesia with propofol and remifentanil compared with sevoflurane anesthesia.Sevoflurane did not induce significant changes in collagen- or ADP-induced platelet aggregation.
CONCLUSIONS
Total intravenous anesthesia with propofol and remifentanil significantly reduced collagen-induced platelet aggregation intraoperatively, while inhalation anesthesia with sevoflurane did not reduce collagen-or ADP-induced platelet aggregation at all.

Keyword

platelet aggregation; propofol; remifentanil; sevoflurane; total intravenous anesthesia

MeSH Terms

Adenosine Diphosphate
Anesthesia
Anesthesia, Inhalation
Anesthesia, Intravenous
Anesthetics
Anesthetics, Inhalation
Blood Platelets
Hematocrit
Hemoglobins
Hip
Humans
Methyl Ethers
Partial Thromboplastin Time
Piperidines
Platelet Aggregation
Platelet Count
Propofol
Prothrombin Time
Adenosine Diphosphate
Anesthetics
Anesthetics, Inhalation
Hemoglobins
Methyl Ethers
Piperidines
Propofol