Anesth Pain Med.  2012 Apr;7(2):125-131.

The effects of sevoflurane and propofol-remifentanil on postoperative hepatic and renal function after laparoscopic and open abdominal surgeries

• Rhee WJ
• Choi SR
• Lee JH
• Park SY
• Lee JY
• Chung CJ

Abstract

BACKGROUND
Sevoflurane and propofol-remifentanil have been known to cause less organ toxicities. However, there are few reports comparing the hepatic and renal effects of both anesthetic regimens. This study was intended to compare sevoflurane with propofol-remifentanil on postoperaitve hepatic and renal function in patients who underwent laparoscopic and open abdominal surgeries retrospectively.
METHODS
Adult patients who had undergone abdominal surgeries were enrolled to conduct retrospective analyses. Total number of 717 patients was largely divided into a laparoscopic surgery (n = 309) and an open surgery (n = 408). The each of laparoscopic and open surgery was divided into a sevoflurane group (Group SEVO) and a propofol-remifentanil group (Group TIVA). Hepatic and renal markers were measured before the operation and on the first and second postoperative day.
RESULTS
Serial changes of postoperative hepatic and renal markers in the laparoscopic and open surgeries were shown in similar patterns between the Group SEVO and the Group TIVA. And there were no statistical differences in the incidence of clinically significant increases in serum SGOT, SGPT, and Cr.
CONCLUSIONS
As sevoflurane and propofol-remifentanil did not show influence on the hepatic and renal function, they may be used safely on patients undergoing the abdominal surgeries.

Keyword

Kidney function; Liver function; Propofol; Remifentanil; Sevoflurane

MeSH Terms

Adult
Alanine Transaminase
Aspartate Aminotransferases
Humans
Incidence
Laparoscopy
Methyl Ethers
Piperidines
Propofol
Retrospective Studies
Alanine Transaminase
Aspartate Aminotransferases
Methyl Ethers
Piperidines
Propofol