A Study of Antimicrobial Sensitivity to the Causative Organism of Urinary Tract Infection

Song, Ho Jun; Kim, Sung Jin

Abstract

PURPOSE: The antibiotic sensitivities to the causative microorganisms of urinary tract infection (UTI) during 2003 were studied in order to propose a better choice of adequate drugs for the treatment of UTI.
MATERIALS AND METHODS
1,527 uropathogens and their antimicrobial sensitivities, in 889 patients admitted to or visiting our hospital during 2003, which revealed isolated causative organisms in the urine cultures, were analyzed.
RESULTS
The incidence of UTI was highest in the 7th decade. The Most common pathogenic organism was E. coli (46.4%), followed by Enterococcus (18.8%), Pseudomonas (7.1%), Klebsiella (5.7%) and Staphylococcus (4.5%). The antimicrobial sensitivities for gram-negative organisms, imipenem, aminoglycoside, ciprofloxacin showed relatively higher sensitivities than for TMP/SMX and ampicillin. In gram-positive organisms, vancomycin and aminoglycoside showed higher sensitivities than any of the other antimicrobial agents. Most of the antimicrobial agents had better sensitive rates in the outpatients.
CONCLUSIONS
E. coli was the most common single organism causing UTI, and showed more resistance to the first recommended drugs, TMP/SMX and ampicillin. Our results imply that recommended the drugs for UTI should be aminoglycoside and ciprofloxacin for inpatients and outpatients, respectively. Aminoglycoside can be used as an alternative to these drugs as a primary empirical antimicrobial agents for UTI.