Korean J Anesthesiol.  2002 Dec;43(6):693-697. 10.4097/kjae.2002.43.6.693.

Optimal Target Concentration of Alfentanil for the Sedation of Urologic Surgical Patients

• Kim DH
• Kim JW

• KMID: 1860628
• DOI: http://doi.org/10.4097/kjae.2002.43.6.693

Abstract

BACKGROUND: The purpose of this study was to define the optimal target concentration of alfentanil effective in achieving a sedative, antianxiety and analgesic effect during spinal anesthesia in urologic patients.
METHODS
Sixty patients underwent spinal anesthesia with 0.5% hyperbaric bupivacaine 12-18 mg and received a target controlled infusion (TCI) of alfentanil with 0 ng/ml (group A0, n = 15), 20 ng/ml (group A20, n = 15), 30 ng/ml (group A30, n = 15) or 40 ng/ml (group A40, n = 15). Sedation scale, bispectral index (BIS), anxiety level and infusion rate of alfentanil were checked during the operation.
RESULTS
Sedation scale was significantly higher in group A30 (3.3) and A40 (3.8) than group A0 (1.9) and A20 (2.5)(P<0.05). Incidences of intraoperative hypotension, respiratory depression, postoperative nausea and vomiting, and dizziness were significantly higher in group A40 than the other groups (P<0.05). There were no significant differences in BIS, anxiety level and incidences of recall of the operative procedure among the groups (P<0.05).
CONCLUSIONS
TCI of alfentanil with 30 ng/ml produces effective sedation and antianxiety effect without significant side effects during spinal anesthesia.

Keyword

Alfentanil; sedation; spinal anesthesia; target-controlled infusion (TCI)

MeSH Terms

Alfentanil*
Anesthesia, Spinal
Anti-Anxiety Agents
Anxiety
Bupivacaine
Dizziness
Humans
Hypotension
Incidence
Postoperative Nausea and Vomiting
Respiratory Insufficiency
Surgical Procedures, Operative
Alfentanil
Anti-Anxiety Agents
Bupivacaine