Korean J Anesthesiol.  2004 Apr;46(4):386-392. 10.4097/kjae.2004.46.4.386.

The Effects of Additional Alfentanil for Sedation during the Endoscopic Retrograde Cholangiopancreatography

• Yim KH
• Kim ST

• KMID: 2299046
• DOI: http://doi.org/10.4097/kjae.2004.46.4.386

Abstract

BACKGROUND
Propofol can be used as a sedative. And, opioids are also frequently used to relieve pain or to induce sedation during monitored anesthetic care. The objectives of this study were to evaluate the effects of additional alfentanil for sedation.
METHODS
Forty-four patients scheduled for ERCP (endoscopic retrograde pancreatocholangiography) were allocated to one of two groups (group 1: propofol without alfentanil, group 2: propofol with alfentanil). In group 2, we mixed propofol with 1,000microgram alfentanil, and administered propofol using a target controlled infusion (TCI). During ERCP, we checked oxygen saturation, systolic blood pressure, heart rate, complications (hypoxemia, agitation, bradycardia, tachycardia). After the procedure, we also checked recovery characteristics; complications (nausea/vomiting, itching, urinary retention, soar throat), and satisfaction scores by using the VAS system (0-100 mm, 0 mm: no satisfaction at all, 100 mm: perfect satisfaction).
RESULTS
There were no significant differences between the two groups in terms of the recovery characteristics, incidence of complications and the satisfaction score of endoscopist or patients. And the total amounts of propofol used were not significantly different. Only SPO2, systolic blood pressure and heart rate showed slight differences, but these were not clinically significant.
CONCLUSIONS
We concluded that the sedation using propofol mixed with 1,000microgram alfentanil has no merit compared with plain propofol.

Keyword

alfentanil; endoscopic retrograde pancreatocholangiography; propofol; sedation

MeSH Terms

Alfentanil*
Analgesics, Opioid
Blood Pressure
Bradycardia
Cholangiopancreatography, Endoscopic Retrograde*
Dihydroergotamine
Heart Rate
Humans
Incidence
Oxygen
Propofol
Pruritus
Urinary Retention
Alfentanil
Analgesics, Opioid
Dihydroergotamine
Oxygen
Propofol