Korean J Anesthesiol.  2007 Mar;52(3):306-309. 10.4097/kjae.2007.52.3.306.

Comparison of Sedation Anesthesia between Midazolam and Midazolam/Alfentanil: for Prolotherapy and Intramuscular Stimulation

• Jo D
• Kim S
• Lee H
• Kim M

• KMID: 1937595
• DOI: http://doi.org/10.4097/kjae.2007.52.3.306

Abstract

BACKGROUND
The presence of pain during interventional pain management such as prolotherapy and intramuscular stimulation is stressful to patients and can affect the treatment outcome. We studied the safety and efficacy of two drug regimens: midazolam alone and midazolam/alfentanil for sedation anesthesia during prolotherapy and intramuscular stimulation.
METHODS
Fifty three patients received either midazolam 0.04-0.08 mg/kg (Group M) or midazolam 0.01-0.02 mg/kg with alfentanil 4-8microgram/kg (Group A) for prolotherapy or intramuscular stimulation. We recorded the pain response, sedation score and side effects during the procedure, as well as amnesia, satisfaction and time to discharge after the procedure.
RESULTS
Both drug regimens had significant sedation scores, amnesia and overall provided patient satisfaction. The treatment of pain was superior in Group A. Respiratory depression of three patients occurred in Group A. The time to discharge was longer in Group M.
CONCLUSIONS
Midazolam and midazolam/alfentanil used for sedation anesthesia during prolotherapy and intramuscular stimulation were both effective; however, midazolam alone was the safer approach.

Keyword

alfentanil; intramuscular stimulation; midazolam; prolotherapy; sedation anesthesia

MeSH Terms

Alfentanil
Amnesia
Anesthesia*
Humans
Midazolam*
Pain Management
Patient Satisfaction
Respiratory Insufficiency
Treatment Outcome
Alfentanil
Midazolam