Korean J Pediatr.  2010 Jan;53(1):41-47. 10.3345/kjp.2010.53.1.41.

Serum interleukin-6, tumor necrosis factor-alpha and adiponectin levels in Kawasaki disease

• Ahn J
• Kim HG
• Sohn S
• Hong YM

• KMID: 1837780
• DOI: http://doi.org/10.3345/kjp.2010.53.1.41

Abstract

PURPOSE
Adiponectin is an endogenous modulator of vascular remodeling that suppresses vascular inflammation. However, the role of adiponectin in Kawasaki disease (KD) has not been elucidated. The purpose of this study is to investigate the correlation between serum adiponectin level and several parameters, such as interleukin (IL)-6, tumor necrosis factor (TNF)-alpha, lipid profile, and C reactive protein (CRP), and to clarify the association between adiponectin and cardiac function.
METHODS
Twenty-two KD patients (22 patients in acute phase and 20 patients in subacute phase) were enrolled in the study group. The control group consisted of 31 subjects (13 febrile patients and 18 healthy children). Both groups underwent blood sampling and tissue Doppler imaging (TDI).
RESULTS
CRP was significantly increased in the KD group compared with the control group. There were no significant differences in serum TNF-alpha, IL-6, and adiponectin levels between groups. However, a negative correlation was found between adiponectin level and CRP level or platelet count. Systolic myocardial velocity and A myocardial velocity measured by TDI were decreased significantly in the acute KD group compared with the subacute KD group and control group. Positive correlations were found between adiponectin level and systolic myocardial velocity or A myocardial velocity.
CONCLUSION
In acute KD patients, low adiponectin level was related to severe inflammatory reactions and decreased left ventricular functions.

Keyword

Kawasaki disease; Adiponectin; Echocardiography

MeSH Terms

Adiponectin
C-Reactive Protein
Echocardiography
Humans
Inflammation
Interleukin-6
Interleukins
Mucocutaneous Lymph Node Syndrome
Platelet Count
Tumor Necrosis Factor-alpha
Ventricular Function, Left
Adiponectin
C-Reactive Protein
Interleukin-6
Interleukins
Tumor Necrosis Factor-alpha