J Korean Soc Pediatr Endocrinol.  2009 Jun;14(1):19-24.

Clinical Course of Childhood and Adolescence Onset Type 2 Diabetes Mellitus

• Yun KA
• Lee YA
• Shin CH
• Yang SW

Abstract

PURPOSE:Worldwide incidence of type 2 diabetes mellitus in youth is increased for last 3 decades. We reviewed the clinical characteristics of the patients and their long term complications.
METHODS
We reviewed the medical data of 69 patients who were diagnosed type 2 diabetes mellitus at Seoul National University Children's Hospital before the age of 18 years between January 1991 and December 2007.
RESULTS
Forty seven patients (68.1%) developed after 2000. The mean age of onset was 13.1+/-2.0 years. Forty seven (69.1%) patients had family history of diabetes mellitus and forty six (66.6%) patients had overweight or obesity. Thirteen (22.4%) patients were small for gestational age but their body mass index wasn't increased compared to that of appropriate for gestational age at the onset of disease. There were 7 patients who had microvascular complication and the mean disease duration was 9.1+/-3.3 years. Hemoglobin A1c was not increased in the complication group compared to the complication-free group.
CONCLUSION
The number of childhood and adolescence onset type 2 diabetes mellitus was increased. The proportion of small for gestation age was high and the long term complication developed in adolescence or early adult life. Early intervention of the risk factors and regular evaluation of the complications are needed and systematized follow-up of small for gestational age is also necessary.

Keyword

Diabetes Mellitus; Type 2; Infant; Small for gestational age; Diabetes complications; Adolescent; Childhood

MeSH Terms

Adolescent
Adult
Age of Onset
Body Mass Index
Diabetes Complications
Diabetes Mellitus
Diabetes Mellitus, Type 2
Early Intervention (Education)
Follow-Up Studies
Gestational Age
Hemoglobins
Humans
Incidence
Infant
Obesity
Overweight
Pregnancy
Risk Factors
Hemoglobins