Ann Pediatr Endocrinol Metab.  2012 Dec;17(4):211-218. 10.6065/apem.2012.17.4.211.

Genetics in Diabetes Mellitus - Contribution to the Classification and Management

Affiliations
  • 1Department of Pediatrics, Dankook University Hospital, Dankook University College of Medicine, Cheonan, Korea. dryujs@dankook.ac.kr

Abstract

Diabetes mellitus (DM) can be classified as type 1, type 2, and other specific types according to the underlying causes. Other specific types include genetic defects of beta-cell function, insulin action, and other genetic syndromes associated with diabetes. Most childhood diabetes has been thought of as type 1 diabetes mellitus (T1DM), but the incidence of type 2 (T2DM) in childhood is rapidly increasing and it can be caused by monogenic defect. In some cases, it might not be easy to determine the type of diabetes and to choose the appropriate treatment. Many susceptible genes to the development of T1DM, T2DM as well as the causative genes of the monogenic diabetes have been identified due to the development of genome-wide association studies, candidate gene analysis and familial linkage studies. Study of the genetic factors in diabetes mellitus is valuable because it enables more appropriate management, and better prediction of disease progression. Therefore, it is important to consider the genetic factors in the management of childhood diabetes.

Keyword

Diabetes mellitus, type 1; Diabetes mellitus, type 2; Neonatal; Genetics

MeSH Terms

Diabetes Mellitus
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Disease Progression
Genetic Association Studies
Genome-Wide Association Study
Incidence
Insulin
Insulin
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