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A case of diabetic ketoacidosis and hyperosmolar hyperglycemic state complicated with iatrogenic left femoral arterial thrombosis in a 14-year-old girl with newly diagnosed type 2 diabetes mellitus

Kim YJ, Kim YH

Although diabetic ketoacidosis (DKA) is a major cause of morbidity and mortality of type 1 diabetes mellitus, DKA also occurs in ketosis-prone type 2 diabetes. Recently, cases of DKA associated...
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Non-Insulin Antidiabetes Treatment in Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Cai X, Lin C, Yang W, Nie L, Ji L

In order to evaluate the efficacy and side effects of the non-insulin antidiabetes medications as an adjunct treatment in type 1 diabetes mellitus (T1DM), we conducted systematic searches in MEDLINE,...
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Association of Urinary N-Acetyl-β-D-Glucosaminidase with Cardiovascular Autonomic Neuropathy in Type 1 Diabetes Mellitus without Nephropathy

Choi MS, Jun JE, Park SW, Yoo JH, Ahn J, Kim G, Jin SM, Hur KY, Lee MK, Kim JH

Background: Cardiovascular autonomic neuropathy (CAN) is a common microvascular complication of diabetes and related to albuminuria in diabetic nephropathy (DN). Urinary N-acetyl-β-D-glucosaminidase (uNAG) is a renal tubular injury marker which...
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Clinical Characteristics, Management, and Potential Biomarkers of Endocrine Dysfunction Induced by Immune Checkpoint Inhibitors

Iwama S, Kobayashi T, Arima H

Immune-related adverse events (irAEs) affecting the endocrine glands are among the most frequent irAEs induced by immune checkpoint inhibitors (ICIs) and include hypopituitarism, primary adrenal insufficiency, thyrotoxicosis, hypothyroidism, hypoparathyroidism, and...
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Current Advances of Artificial Pancreas Systems: A Comprehensive Review of the Clinical Evidence

Moon SJ, Jung I, Park CY

Since Banting and Best isolated insulin in the 1920s, dramatic progress has been made in the treatment of type 1 diabetes mellitus (T1DM). However, dose titration and timely injection to...
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The rs2304256 Polymorphism in TYK2 Gene Is Associated with Protection for Type 1 Diabetes Mellitus

Pellenz FM, Dieter C, Duarte GCK, Canani LH, de Souza BM, Crispim D

Background: Tyrosine kinase 2 (TYK2) is a candidate gene for type 1 diabetes mellitus (T1DM) since it plays an important role in regulating apoptotic and pro-inflammatory pathways in pancreatic β-cells...
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Suitability of denervated muscle flaps as recipient sites for pancreatic islet cell transplantation

Park JL, Kim T, Kim BK

Background Extensive research has been conducted on islet transplantation as a possible cure for diabetes. Islet transplantation in the liver via the portal vein has shown remarkable results, but numerous...
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Age at Diagnosis and the Risk of Diabetic Nephropathy in Young Patients with Type 1 Diabetes Mellitus

Baek JH, Lee WJ, Lee BW, Kim SK, Kim G, Jin SM, Kim JH

Background The aim of this study was to evaluate characteristics and risk of diabetic complications according to age at diagnosis among young adults with type 1 diabetes mellitus (T1DM). Methods A total of...
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Persistent Anxiety Is Associated with Higher Glycemia Post-Transition to Adult Services in Asian Young Adults with Diabetes

Zhu L, Chandran SR, Tan WB, Xin X, Goh SY, Gardner DSL

Background There is little longitudinal information on psychological burden and metabolic outcomes in young adults with diabetes (YAD) in Asia. We aimed to evaluate the association between psychological status and glycemia...
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Therapeutic Effects of Fibroblast Growth Factor-21 on Diabetic Nephropathy and the Possible Mechanism in Type 1 Diabetes Mellitus Mice

Weng W, Ge T, Wang Y, He L, Liu T, Wang W, Zheng Z, Yu L, Zhang C, Lu X

BackgroundFibroblast growth factor 21 (FGF21) has been only reported to prevent type 1 diabetic nephropathy (DN) in the streptozotocin-induced type 1 diabetes mellitus (T1DM) mouse model. However, the FVB (Cg)-Tg...
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Type 1 Diabetes Home Care Project and Educational Consultation

Shin EC

Type 1 diabetes mellitus (T1DM) is an autoimmune disease that absolutely lacks insulin production. It requires lifelong care, including proper diet and exercise, along with insulin administration. It is important...
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Incidence and Prevalence of Type 1 Diabetes Mellitus among Korean Children and Adolescents between 2007 and 2017: An Epidemiologic Study Based on a National Database

Chae HW, Seo GH, Song K, Choi HS, Suh J, Kwon A, Ha S, Kim HS

Background: The incidence of type 1 diabetes mellitus (T1DM) among children is high in Europe and the USA and relatively low in Asia, including Korea. The present study aimed to...
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Differential Profile of Plasma Circular RNAs in Type 1 Diabetes Mellitus

Li Y, Zhou Y, Zhao M, Zou J, Zhu Y, Yuan X, Liu Q, Cai H, Chu CQ, Liu Y

Background No currently available biomarkers or treatment regimens fully meet therapeutic needs of type 1 diabetes mellitus (T1DM). Circular RNA (circRNA) is a recently identified class of stable noncoding RNA that...
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High Proportion of Adult Cases and Prevalence of Metabolic Syndrome in Type 1 Diabetes Mellitus Population in Korea: A Nationwide Study

Lee YB, Han K, Kim B, Jin SM, Lee SE, Jun JE, Ahn J, Kim G, Kim JH

BACKGROUND: The prevalence and incidence of type 1 diabetes mellitus (T1DM) in all age groups and the prevalence of metabolic syndrome in patients with T1DM in Korea were estimated. METHODS: The...
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Latent Autoimmune Diabetes in Adults: Current Status and New Horizons

Pozzilli P, Pieralice

Autoimmune diabetes is a heterogeneous disease which can arise at any age. Subjects with adult-onset autoimmune diabetes who do not necessitate insulin-therapy for at least 6 months after diagnosis are...
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Diabetic Ketoacidosis Following Colonoscopy in Fulminant Type 1 Diabetes: A Case Report

Choi DH, Kim BY, Jung CH, Kim CH, Kang SK, Mok JO

Fulminant type 1 diabetes is a distinct subtype of type 1 diabetes mellitus that is characterized by sudden, complete destruction of pancreatic beta cells at the disease onset. Since the...
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Alginate-Catechol Cross-Linking Interferes with Insulin Secretion Capacity in Isolated Murine Islet Cells

Kim YS, Cho SW, Ko B, Shin J, Ahn CW

Over the past three decades, human pancreatic islet isolation and transplantation techniques have developed as a routine clinical procedure for selected patients with type 1 diabetes mellitus. However, due to...
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The Role of Negative Affect in the Assessment of Quality of Life among Women with Type 1 Diabetes Mellitus

Gawlik NR, Bond MJ

BACKGROUND: The purpose of this study is to determine the impact of negative affect (defined in terms of lack of optimism, depressogenic attributional style, and hopelessness depression) on the quality...
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Recent Updates on Type 1 Diabetes Mellitus Management for Clinicians

Iqbal A, Novodvorsky P, Heller SR

Type 1 diabetes mellitus (T1DM) is a chronic autoimmune condition that requires life-long administration of insulin. Optimal management of T1DM entails a good knowledge and understanding of this condition both...
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Frequency of Self-Monitoring of Blood Glucose during the School Day Is Associated with the Optimal Glycemic Control among Korean Adolescents with Type 1 Diabetes

Joo EY, Lee JE, Kang HS, Park SG, Hong YH, Shin YL, Sohn M

BACKGROUND: This study aimed to evaluate the relationship between the frequency of self-monitoring of blood glucose (SMBG) and glycosylated hemoglobin (HbA1c) levels among Korean adolescents with type 1 diabetes mellitus...
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