Clin Pediatr Hematol Oncol.  2013 Oct;20(2):108-111.

Successful Selective CD34+ Cell Infusion after Late Graft Failure of Hematopoietic Stem Cell Transplantation in Two Cases of Severe Aplastic Anemia

• Hahn SM
• Sol IS
• Jin SL
• Kim HS
• Han JW
• Kim SH
• Lyu CJ

Abstract

Matched sibling bone marrow transplantation (BMT) in severe aplastic anemia (SAA) has been known as the treatment of choice in children and young adults. To overcome graft failure, second stem cell transplantation showed good results in previous studies. Here we report two cases of aplastic anemia patients with late graft failure and resulted in successful complete recovery after selective CD34+ cell boost infusion. The patients previously underwent allogeneic BMT from HLA-matched sibling donors and the engraftment was achieved although their CBC started to decrease respectively 3 months and 11 months after transplantation. Both patients received selective CD34+ cell infusion without additional conditioning therapy. Their CBC showed significant improvement and they are doing well without transfusion or complications. From this study we suggest that selected CD34+ cell boost treatment can be a promising curative treatment for late graft failure after matched sibling BMT in SAA patients.

Keyword

Aplastic anemia; Late graft rejection; Selective CD34+ cell infusion

MeSH Terms

Anemia, Aplastic*
Behavior Therapy
Bone Marrow Transplantation
Child
Hematopoietic Stem Cell Transplantation*
Hematopoietic Stem Cells*
Humans
Siblings
Stem Cell Transplantation
Tissue Donors
Transplants*
Young Adult