J Korean Med Sci.  2009 Aug;24(4):744-746. 10.3346/jkms.2009.24.4.744.

Successful Salvage Unrelated Umbilical Cord Blood Transplantation with Two Units After Engraftment Failure with Single Unit in Severe Aplastic Anemia

  • 1Division of Hematology/Oncology, Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea. hsahn@snu.ac.kr


Severe aplastic anemia (SAA) patients without an HLA-matched sibling donor need alternative treatment options. Umbilical cord blood transplantation (UCBT) has become an alternative means for treating various diseases, but it has not been proved to be a satisfactory method to treat SAA. Here, we report the case of a girl who underwent successful two-unit UCBT after engraftment failure with a single unit. Twounit UCBT is proposed to have better engraftment potential and to offer a better chance of survival, according to some reports. Increased cell dose and graft-versus-graft reaction could contribute to these advantages. With this promising result, two-unit UCBT could be an alternative treatment option for patients with SAA without an HLA-matched donor.


Anemia, Aplastic; Cord Blood Stem Cell Transplantation; Two-unit

MeSH Terms

Anemia, Aplastic/diagnosis/*therapy
Child, Preschool
*Cord Blood Stem Cell Transplantation
Graft vs Host Disease/immunology
HLA Antigens/immunology
In Situ Hybridization, Fluorescence


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