J Korean Med Sci.  2009 Aug;24(4):744-746. 10.3346/jkms.2009.24.4.744.

Successful Salvage Unrelated Umbilical Cord Blood Transplantation with Two Units After Engraftment Failure with Single Unit in Severe Aplastic Anemia

• Lee JW
• Kang HJ
• Kim EK
• Shin HY
• Ahn HS

• KMID: 1779214
• DOI: http://doi.org/10.3346/jkms.2009.24.4.744

Abstract

Severe aplastic anemia (SAA) patients without an HLA-matched sibling donor need alternative treatment options. Umbilical cord blood transplantation (UCBT) has become an alternative means for treating various diseases, but it has not been proved to be a satisfactory method to treat SAA. Here, we report the case of a girl who underwent successful two-unit UCBT after engraftment failure with a single unit. Twounit UCBT is proposed to have better engraftment potential and to offer a better chance of survival, according to some reports. Increased cell dose and graft-versus-graft reaction could contribute to these advantages. With this promising result, two-unit UCBT could be an alternative treatment option for patients with SAA without an HLA-matched donor.

Keyword

Anemia, Aplastic; Cord Blood Stem Cell Transplantation; Two-unit

MeSH Terms

Anemia, Aplastic/diagnosis/*therapy
Child, Preschool
*Cord Blood Stem Cell Transplantation
Female
Graft vs Host Disease/immunology
HLA Antigens/immunology
Histocompatibility
Humans
In Situ Hybridization, Fluorescence

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