J Korean Med Sci.  2005 Feb;20(1):65-69. 10.3346/jkms.2005.20.1.65.

Lack of Association between Hepatitis B Virus Infection and Polymorphism of Mannose-Binding Lectin Gene in Korean Population

• Cheong JY
• Cho SW
• Lim SK
• Shin DH
• Yoon SK
• Lee JE
• Hahm KB
• Kim JH

• KMID: 1781727
• DOI: http://doi.org/10.3346/jkms.2005.20.1.65

Abstract

Mannose-binding lectin (MBL) plays an important role in immune defense. This study was undertaken to investigate the association between hepatitis B virus infection and polymorphisms of MBL gene. We assessed the single nucleotide polymorphism at codon 54 in exon 1 of MBL in patients with hepatitis B virus infection and HBsAg negative controls in Korean population. A total of 498 enrolled subjects was classified into four groups. Group 1; Clearance, Group 2; Inactive healthy carrier, Group 3; Chronic hepatitis, Group 4; Liver cirrhosis. MBL gene polymorphisms at codon 54 led to three genotypes (G/G, G/A, A/A). When we divided subjects into clearance group (group 1) and persistence group (group 2-4), G/G genotype and A-allele carrier were observed in 55.6% and 44.4% in clearance group, 64.8% and 35.2% in persistence group (p=0.081), respectively. When hepatitis B virus persistent cases were divided into inactive healthy carrier (group 2) and disease progression group (group 3 and 4), MBL gene polymorphisms at codon 54 were not related to disease progression (p=0.166). MBL gene polymorphism at codon 54 was not associated with the clearance of hepatitis B virus infection nor progression of disease in chronic hepatitis B virus infection.

Keyword

Mannose-Binding Lectin; Hepatitis B; Polymorphism, Genetic

MeSH Terms

Adult
Alleles
Codon
Disease Progression
Female
Fibrosis
Genotype
Hepatitis
Hepatitis B/*genetics/*metabolism
Hepatitis B virus/*metabolism
Heterozygote
Humans
Korea
*Lectins
Male
Mannose-Binding Lectin/*chemistry/*genetics
Middle Aged
*Polymorphism, Genetic
Polymorphism, Single Nucleotide
Research Support, Non-U.S. Gov't

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