Korean J Vet Res.
2014 Sep;54(3):189-192.
Antibacterial and therapeutic effects of a combination of Sophora flavescens and Glycyrrhiza uralensis Fischer ethanol extracts on mice infected with Streptococcus pyogenes
- Affiliations
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- 1Tongyeong National Quarantine Station, Ministry of Health & Welfare, Tongyeong 650-110, Korea.
- 2Graduate School of Public Health, Gyeongsang National University, Jinju 660-751, Korea. hujang@gnu.ac.kr
- 3Department of Industrial Systems Engineering, Engineering Research Institute, Gyeongsang National University, Jinju 600-701, Korea.
- 4Department of Medical Humanities and Social Medicine, College of Medicine, Kosin University, Busan 602-703, Korea.
- 5Department of Computer Information, Gyeongnam Provincial Namhae College, Namhae 668-801, Korea.
- 6College of Veterinary Medicine, Research Institute of Live Sciences, Gyeongsang National University, Jinju 600-701, Korea.
Abstract
- This study evaluated the antibacterial effects of a mixture of Sophorae radix and Glycyrrhiza uralensis Fischer (1 : 1) ethanol extracts (SGE) on mice infected with Streptococcus (S.) pyogenes. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration of SGE necessary for antibacterial effects against S. pyogenes were 20 microg/mL. Based on the time-kill curves for S. pyogenes, SGE was effective at 4x MIC after 16 h. On Day 12 after challenge, the survival rate of mice treated with 2.0 mg/kg SGE was 60%. In conclusion, SGE had potent in vitro and in vivo antibacterial activities against S. pyogenes.
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