J Korean Pediatr Soc.  1982 Jan;25(1):52-57.

Late Hemorrhagic Disease of Infancy due to Vitamin K Dependent Factor Deficiency

• Lee KI
• Kim YS
• Lee SB
• Koo JH

Abstract

A clinical study was done on 9 children with 10 episodes, who were admitted to our pediatric ward under the diagnosis of late hemorrhagic disease of infancy due to vitamin K dependent factor deficiency. Study period was past 2 years, from September 1979 to May 1981. The following results were obtained. This disorder occurred most frequently during early infancy, with male predominence, male female ratio being 4:1. And breast feeding was noted in 6, with history of previous medication for URI in 7. GIT was the most common site of bleeding occurring in 9 cases, followed by CNS in 3, skin in 1 and nose in 1. Anemia, probably due to blood loss, was seen in 8 cases, and dehydration, oral thrush, fever, irritability, mental change and convulsion were seen in small number of cases. Initial laboratory findings showed prolonged PT and PTT with normal platelet count in all cases. After vitamin K therapy, PT and PTT became normal in majority of cases. Prompt response to vitamin K therapy within 24 hours was noted in 6, prolonged response over 3 days in 2, and one patient showed recurrence at 2(1/2) months after complete recovery from first episode.

Keyword

Late hemorrhagic disease of infancy; vitamin K deficiency

MeSH Terms

Anemia
Breast Feeding
Candidiasis, Oral
Child
Dehydration
Diagnosis
Female
Fever
Hemorrhage
Humans
Male
Nose
Platelet Count
Recurrence
Seizures
Skin
Vitamin K Deficiency
Vitamin K*
Vitamins*
Vitamin K
Vitamins