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Clinical Review of Commercially-Available Anti-Snoring Devices

Lee KI, Choi JH

Snoring is a common issue that negatively affects sleep quality. Generally, simple snorers without sleep apnea may be managed with various therapeutic options such as behavioral treatments, mandibular advancement devices...
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Tobacco Smoking Could Accentuate Epithelial-Mesenchymal Transition and Th2-Type Response in Patients With Chronic Rhinosinusitis With Nasal Polyps

Lee KI, Han Y, Ryu JS, In SM, Kim JY, Park JS, Kim JS, Kim J, Youn J, Park SR

Tobacco smoking (TS) has been known as one of the most potent risk factors for airway inflammatory diseases. However, there has been a paucity of information regarding the immunologic alteration...
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Dissection Manual for Open Rhinoseptoplasty in a Silicone Nose Model

Lee KI, Won TB, Hyun S, Song H, Jang YJ, Choi JY, Hong SN, Kim HY, Kim JS, Kim SW, The Korean Academy of Facial Plastic and Reconstructive Surgery

Open rhinoseptoplasty has been widely performed in the field of otorhinolaryngology. However, from the perspective of beginners, rhinoseptoplasty is a hard-to-learn surgery that involves a relatively steep learning curve. Therefore,...
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A Novel Powered Nasal Irrigation After Endoscopic Sinus Surgery in Patients With Chronic Rhinosinusitis: A Preliminary Study

Lee KI, Kim JY, Son S, Kim SH, Kim MH, Nam E, In SM

Background and Objectives We aimed to compare the efficacy of a novel powered irrigation system with that of the manual bottle-squeeze method for postoperative healing after endoscopic sinonasal surgery (ESS). Subjects...
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Clinical application of insect-based diet in canine allergic dermatitis

Lee KI, Chae Y, Yun T, Koo Y, Lee D, Kim H, So KM, Cho WJ, Kim HJ, Yang MP, Kang BT

The objective of this study was to evaluate the beneficial effects of the short-term application of insect-based diet in canine allergic dermatitis. Total 19 atopic dogs with concurrent cutaneous adverse...
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Practical Review of Biologics in Chronic Rhinosinusitis With Nasal Polyps

Lee KI, Ryu G, Yoo SH, Kim YM, Mo JH, Shin SH

Well-characterized in chronic rhinosinusitis, type 2 inflammation is frequently associated with nasal polyps, comorbid asthma, and nonsteroidal anti-inflammatory drug hypersensitivity. Despite medical and surgical treatment, it recurs in a significant...
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Clinical Reviews of COVID-19 for Otorhinolaryngologists

Lee KI, Kim DK, Mo JH

The novel SARS-CoV-2 virus that causes COVID-19 has emerged rapidly and the virus has caused a global pandemic since it was first diagnosed in December 2019. SARS-CoV-2 is the seventh...
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Practical Recommendation of COVID-19 for Otorhinolaryngologists

Lee KI, Kim DK, Lee KH, Mo JH, Kim SW

Otorhinolaryngologic symptoms such as cough, rhinorrhea, anosmia, ageusia, and fever can precede development of COVID-19. Otolaryngologists are vulnerable to potential COVID-19 infection because early cases of COVID-19 have been asymptomatic...
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The impact of air pollution on allergic rhinitis

Lee KI, Chung YJ, Mo JH

Recently, air pollution has become more and more severe globally and has decreased the quality of life significantly in subjects with or without allergic diseases. Air pollution more severely affects...
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Recombinant Rv0753c Protein of Mycobacterium tuberculosis Induces Apoptosis Through Reactive Oxygen Species-JNK Pathway in Macrophages

Lee KI, Choi S, Choi HG, Kebede SG, Dang TB, Back YW, Park HS, Kim HJ

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains one of the most important infectious diseases worldwide. Mtb and its culture filtrates or sonic extracts induce apoptosis in macrophages. However, there...
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Strain-Specific Differences in House Dust Mite (Dermatophagoides farinae)-Induced Mouse Models of Allergic Rhinitis

Lee KI, Bae JS, Kim EH, Kim JH, Lyu L, Chung YJ, Mo JH

Objectives. Limited information is available regarding strain-related differences in mouse models of allergic rhinitis induced by Dermatophagoides farinae (Der f1). In this study, we compared differences between two mouse strains...
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Advantages and Necessities of Telehealth Care Service

Kim JY, Lee KI

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Clinical trial of oral administration of Bifidobacterium longum in dogs with atopic dermatitis

Lee KI, Yun T, Ham J, Lee WK, Kang JH, Yang MP, Kang BT

This study assessed the effects of probiotics in canine atopic dermatitis (AD). We enrolled 11 client-owned dogs with AD and randomly allocated them to two groups. The probiotics group (n...
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Vascular Leiomyoma of the Nasal Floor: The Risk of Misdiagnosis

Lee KI, An HG, Hong SR, Kim JY, In SM

Vascular leiomyoma (VL) is a rare tumor, particularly in the sinonasal region. The etiology of VL is unclear and there are a number of theories regarding how VL develops. To...
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Reserpine treatment activates AMP activated protein kinase (AMPK)

Park R, Lee KI, Kim H, Jang M, Ha TK, Oh WK, Park J

Reserpine is a well-known medicine for the treatment of hypertension, however the role of reserpine in cell signaling is not fully understood. Here, we report that reserpine treatment induces the...
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Brain morphology according to age, sex, and handedness

Kang SJ, Kang KA, Jang H, Lee JY, Lee KI, Kwoen MS, Kim JS, Park KM

In this article, we review the differences of the brain morphology according to age, sex, and handedness. Age is a well-known factor affecting brain morphology. With aging, progressive reduction of...
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p21-activated kinase 1 is allostericallyInhibited by naphthoquinone (NQ) derivatives

Oh SW, Lee KI, Choi JK, Kim KA, Kim EG, Shin EY

The p21-activated kinases (PAKs) are a family of serine/threonine protein kinases and activated by binding with activated Rho GTPases such as Rac or Cdc42. PAKs regulate actin cytoskeletal remodeling, cell...
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Effectiveness of Rapidrhino® Packing in Patients Who Visited Emergency Room due to Anterior Epistaxis

Kim B, Kwon MO, Yang CJ, Cho IS, Lee KI

PURPOSE: Although there are many treatment options for managing epistaxis, little is known about their outcomes in the emergency department (ED). In this study, we evaluated the management of epistaxis,...
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Small molecules that allosterically inhibit p21-activated kinase activity by binding to the regulatory p21-binding domain

Kim DJ, Choi CK, Lee CS, Park MH, Tian X, Kim ND, Lee KI, Choi JK, Ahn JH, Shin EY, Shin I, Kim EG

p21-activated kinases (PAKs) are key regulators of actin dynamics, cell proliferation and cell survival. Deregulation of PAK activity contributes to the pathogenesis of various human diseases, including cancer and neurological...
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Analysis of Changes in Anterior, Posterior and Total Corneal Astigmatism after On-Axis Cataract Surgery

Lee KI, Park YL, Kim HS

PURPOSE: To assess the changes in anterior, posterior, and total corneal astigmatism after cataract surgery with on-axis clear corneal incision cataract surgery. METHODS: This study included 48 eyes (24 eyes with...
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