Korean Circ J.  1979 Dec;9(2):43-49. 10.4070/kcj.1979.9.2.43.

The Clinical Evaluation of Antihypertensive Effect of Minizide(R)

• Rho JW
• Kang JC
• Park KO
• Park OK

• KMID: 1668287
• DOI: http://doi.org/10.4070/kcj.1979.9.2.43

Abstract

Although a variety of agents have been introduced for the treatment of hypertension, the ideal drug has not yet been discovered. However, among the agents available, prazosin hydrochloride (Minipress(R)) appears to be accepted by the majority of physicians as it lowers blood pressure effectively with relatively low incidence of side effects. It has been considered that the hypotensive effect of prazosin is a result of peripheral vasodilation due to direct relaxation of vascular smooth muscle and blockade of alpha-adrenergic receptors in the arteriolar smooth muscle. Following the development of prazosin. many trials have been designed to potentiate its hypotensive effect by the combination with other agent, especially thiazide or beta blocker. Minizide(R), a preparation that thiazide is added to prazosin, is an example. The antihypertensive effect of Minizide(R) was evaluated in 30 hypertensive subjecs. The results were as follows; 1. The systolic and diastolic blood pressure were effectively lowered in both supine and standing position with the overall response rate of 86.7% as judged to be responsive in one that lost systolic pressure more than 15 mmHg and distolic pressure 10 mmhg. Among 30 cases 18 cases could be maintained with their diastolic pressure below 90 mmHg and 24 cases with their diastolic pressure below 100 mmHg by the end of 8th week of treatment with the daily dose of minizide(R) from a half tablet to two tablets. 2. During the period of 8 weeks, troublesome postural hypotension was not observed in any case. The pulse rate was not accelerated significantly by Minizide(R) treatment. 3. Minimal side effects were recorded in 5 cases; two of mild nausea, one of slight dizziness, one of minimal gastrointestinal irritation symptom and one of mild glucosuria. neither of them hindered the authors from finding the study.

MeSH Terms

Blood Pressure
Dizziness
Heart Rate
Hypertension
Hypotension, Orthostatic
Incidence
Muscle, Smooth
Muscle, Smooth, Vascular
Nausea
Prazosin
Receptors, Adrenergic, alpha
Relaxation
Tablets
Vasodilation
Prazosin
Receptors, Adrenergic, alpha
Tablets