Korean Circ J.  1985 Sep;15(3):461-465. 10.4070/kcj.1985.15.3.461.

Clinical Study on Antihypertensive Effect of Minizide (Prazosin Hydrochloride and Polythiazide)

• Kim HS

• KMID: 1668696
• DOI: http://doi.org/10.4070/kcj.1985.15.3.461

Abstract

The antihypertensive effect of Minizide(0.5mg prazosin hydrochloride and 0.25mg polythiazide per tablet)was evaluated in 30 patients with essential hypertension with a dosage of one tablet a day for four weeks. The results were as follows : 1) Of 30 patients treated with Minizide, 21 patients(70.0%) achieved normalization of blood pressure and 5 patients(16.7%) had good response. 2) Mean drop in systolic and diastolic pressure were 29.0mmHg and 15.9mmHg respectively in supine position(P<0.005). 3) Mean drop in systolic and diastolic pressure were 28.5mmHg and 16.2mmhg respectively in sitting position(P<0.005). 4) In 14 patients(46.7%) among 30 patients treated with Minizide adverse reactions developed. The most frequent one was postural dizziness(23.3%). 5) Most adverse reactions were transient and tolerable. However, in three patients(two patients with postural dizziness and one patient with dry mouth) the medication was stopped due to adverse reactions.

MeSH Terms

Blood Pressure
Dizziness
Humans
Hypertension
Polythiazide
Prazosin
Polythiazide
Prazosin