Korean Circ J.  1975 Jun;5(1):25-30. 10.4070/kcj.1975.5.1.25.

A Clinical Study on Antihypertensive Effects of Prazosin Hydrochloride (Minipress(R))

• Lee YW
• Seo JD

• KMID: 1667820
• DOI: http://doi.org/10.4070/kcj.1975.5.1.25

Abstract

Authors observed the antihypertensive effect of prazosin hydrochloride in 37 cases of essential hypertension and following results were obtained. 1) Results of antihypertensive therapy with praSzosin in 37 hypertensive patients revealed good control in 48.7%, fair in 24.4%, poor in 18.8% and failure in 8.1% of cases. In 73.1% of the cases, good or fair control of blood pressure was resulted. 2) The daily effective doses of prazosin in the majority of patients ranged from 3 to 18mg with an average of 8.5mg. The antihypertensive effect of prazosin appeared after 4.7 weeks of administration. 3) The side effects during treatment with prazosin were postural dizziness in 37.8%, headache in 10.8%, weakness in 8.1%, palpitation, nausea, dry mouth and nasal congestion in 5.4% respectively. There were no side effects in 54.1% of cases.

MeSH Terms

Blood Pressure
Dizziness
Estrogens, Conjugated (USP)
Headache
Humans
Hypertension
Mouth
Nausea
Prazosin*
Estrogens, Conjugated (USP)
Prazosin