Korean J Urol.
1989 Aug;30(4):509-513.
Clinical Effect of Prazosin Hydrochloride in Patient with Benign Prostatic Hypertrophy
- Affiliations
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- 1Department of Urology, Soon Chun Hyang University, College of Medicine, Chun-An Hospital, Chun An, Korea.
Abstract
- The clinical effect of prazosin, an alpha-1-receptor blocking agent, was studied in 31 patients with benign prostatic hypertrophy. The daily dose of 1.5-6 mg of prazosin was given for 2 weeks to 3 months. The efficacy was assessed by using uroflowmetry calculated from maximum flow rate, average flow rate and residual urine volume. The result revealed significant improvement of day time frequency, night time frequency (p<0.05) and maximum and average flow rate (p<0.05). It was suspected that prazosin was the valuable alpha-1-receptor blocker for benign prostatic hypertrophy and worth while to initiate medical treatment before undergoing any surgical intervention or when surgery is contraindicated.
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