Korean Circ J.  1983 Dec;13(2):387-394. 10.4070/kcj.1983.13.2.387.

Effects of Prazosin Alone and in Combination for Treatment of Essential Hypertension

• Ryoo UH

• KMID: 2093167
• DOI: http://doi.org/10.4070/kcj.1983.13.2.387

Abstract

The therapeutic effects of prazosin hydrochloride alone and in combination with diuretic and/or beta-blocker in 41 patients with essential hypertension were evaluated. The results were as follows: 1) Of 28 patients treated with prazosin alone, 18(64.2%) achieved normalization of blood pressure and 7(25.0%) had good response of treatment. 2) Of 16 patients, with inadequate control on initial treatment, treated with prazosin in combination with diuretic and beta-blocker, 14(87.5%) achieved normalization of blood pressure. 3) After therapy with prazosin alone, the mean blood pressure reduced 25/16mmHg(p<0.05/p<0.01). 4) After addition of diuretic or beta-blocker in 6 patients receiving prazosin alone with inadequate response, the mean blood pressure reduced 31/13mmHg(p<0.01/p<0.01). 5) After addition of prazosin in 10 patients receiving diuretic alone or diuretic and beta-blocker but with inadequate control, the mean blood pressure reduced 32/14 mmHg(p<0.01/p<0.01). 6) The side effects were noted in 10 patients(25.0%). The most popular one was dizziness(17.5%), and the next was headache(10.0%).

MeSH Terms

Blood Pressure
Humans
Hypertension*
Prazosin*
Prazosin