Korean J Urol.
1993 Dec;34(6):1043-1047.
Preventive effects of prazosin for urinary retention after epidural anesthesia
- Affiliations
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- 1Department of Urology, Chungnam University, College of Medicine, Taejeon, Korea.
Abstract
- Prazosin blocks the alpha-1 adrenergic receptor of sympathetic nerve. The effects of prazosin in patient with epidural lumbar anesthesia were analyzed with blind test. In a prospective randomized study, we compared a group of 25 patients who received prazosin with a control group of 58 patients. Forty-one( 70.7 %) of 58 patients developed acute urinary retention. In 11 of 25 patients(44 %), who were medicated with prazosin(3mg. per 18 hours) urinary retention was noted ( p >0.05). Mean catheterization rate in urinary retented patients was 1.61 in control group(41 cases), and was 1.27 in prazosin medicated group( 11 case) (p <0.05). Prazosin is an effective drug not only to prevent acute urinary retention but also to reduce the need for catherization.
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