J Korean Neurol Assoc.  1986 Dec;4(2):246-250.

A Case of Cerebral Venous Thrombosis in Paroxysmal Nocturnal Hemoglobinuria

Affiliations
  • 1Department of Neurology, Yonsei University, College of Medicine.
  • 2Department of Internal Medicine, Yonsei University, College of Medicine.

Abstract

Paroxymal nocturnal hemoglobinuria is a kind of intravascular hemolytic anemia due to acquired corpscular defects, and is not rare in this country. The corpscular defect is originated from hematopoietic stem cells, and white blood cells and platelets are also involved. Consequently, the major complications which might affect mortality and morbidity include thrombotic phenomena, especially hepatic and cerebral venous thrombosis. This is a case report of cerebral venous thrombosis with hemiparesis, seizure and change of consciousness in paroxysmal nocturnal hemoglobinuria accompanied by intravascular hemolysis. The diagnosis is confirmed by CT brain scan and cerebral angiography and the patient is effectively treated with antiplatelets, anticonvulsants and steroids.


MeSH Terms

Anemia, Hemolytic
Anticonvulsants
Brain
Cerebral Angiography
Consciousness
Diagnosis
Hematopoietic Stem Cells
Hemoglobinuria
Hemoglobinuria, Paroxysmal*
Hemolysis
Humans
Leukocytes
Mortality
Paresis
Seizures
Steroids
Venous Thrombosis*
Anticonvulsants
Steroids
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