Korean J Obstet Gynecol.  2004 Apr;47(4):748-751.

Delivery in a Patient with Paroxysmal Nocturnal Hemoglobinuria Successfully Managed with Low Molecular Weight Heparin Therapy

• Kim HB
• Chang HJ
• Yang JI
• Kim HS
• Ryu HS
• Kim HC

Abstract

Paroxysmal nocturnal hemoglobinura is a very rare acquired clonal hematopoietic cell disorder leading to chronic intravascular hemolysis caused by abnormal complement activation. Pregnancy in a patient with paroxysmal nocturnal hemoglobinuria is often complicated with thrombosis resulting serious materno-fetal morbidity and mortality. A case of successful maintenance of the pregnancy, delivery and postpartum in a woman at gestational age of 37 weeks and 2 days with paroxysmal nocturnal hemoglobinuria managed with prophylactic transfusions and anticoagulation therapy by low molecular weight heparin is presented with a review of literature.

Keyword

Paroxysmal nocturnal hemoglobinuria; Low molecular weight heparin; Pregnancy

MeSH Terms

Complement Activation
Female
Gestational Age
Hemoglobinuria, Paroxysmal*
Hemolysis
Heparin, Low-Molecular-Weight*
Humans
Mortality
Postpartum Period
Pregnancy
Thrombosis
Heparin, Low-Molecular-Weight