Tuberc Respir Dis.  2004 Sep;57(3):284-288. 10.4046/trd.2004.57.3.284.

A Case of Central Diabetes Insipidus in Patient with Non-small Cell Lung Cancer

• Hwang EM
• Oh YK
• Kim KJ
• Kim YH
• Yoon HK
• Song JS

• KMID: 1656519
• DOI: http://doi.org/10.4046/trd.2004.57.3.284

Abstract

Central diabetes insipidus (DI) is a disease caused by insufficient release of antidiuretic hormone. Central DI with lung cancer is very rare. Most of them are caused by the pituitary metastasis, and rarely, by the paraneoplastic syndromes. Central DI is diagnosed by the water deprivation test. The treatment consists of surgical resection, radiotherapy and administration of desmopressin. We report an unusual case of central DI with non-small cell lung cancer. The diagnosis was confirmed by water deprivation test. After the administration of desmopressin, the urine osmolarity was increased. The patient's symptoms and urine osmolarity were improved by intranasal desmopressin.

Keyword

Non-small cell lung cancer; Central diabetes insipidus

MeSH Terms

Carcinoma, Non-Small-Cell Lung*
Deamino Arginine Vasopressin
Diabetes Insipidus, Neurogenic*
Diagnosis
Humans
Lung Neoplasms
Neoplasm Metastasis
Osmolar Concentration
Paraneoplastic Syndromes
Radiotherapy
Water Deprivation
Deamino Arginine Vasopressin