The Analysis of Gallbladder Bile Acid Concentration in Patients with Colorectal Cancer

Cho, Yun Ju; Hahm, Joon Soo; Choi, Ho Soon; Lee, Yong Wook; Jeon, Yong Cheol; Sohn, Joo Hyun; Yoon, Byung Chul; Lee, Min Ho; Lee, Dong Hu; Kee, Chun Suk; Park, Kyung Nam; Park, Young Seok; Jun, Kyu Young

Abstract

BACKGROUND/AIMS
Changes of bile acid concentration may play an important role in the carcinogenesis of colorectal cancer. We intended to assess the difference in bile acid concentrations between patients with colorectal cancer and controls. METHODS: In 18 patients with colorectal cancer and 10 controls, gallbladder bile was obtained by direct gallbladder puncture and analyzed by high performance liquid chromatography combined with an enzyme method (JASCO method). RESULTS: There was a significant increase in the concentration of chenodeoxycholic acid (CDCA) (41.02+/-18.42 mg/ml) and total bile acids (72.97+/-37.60 mg/ml) (p<0.05) of patients with colorectal cancer as compared with those of controls (CDCA 22.99+/-18.65 mg/ml, total bile acids 42.74+/-35.29 mg/ ml). The concentrations of primary bile acids and the proportion of secondary bile acids in total bile acids were also higher in patients with colorectal cancer than in controls. CONCLUSIONS: Concentrations of CDCA and total bile acids in patients with colorectal cancer were higher than those in controls. These results suggest that the changes in bile acid concentration is related to the pathogenesis of colorectal cancer in Korea.