Korean J Physiol Pharmacol.
1997 Oct;1(5):523-528.
Changes of renal peripheral benzodiazepine receptor in the stress/anxiety response
- Affiliations
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- 1Department of Pharmacology, College of Medicine, Yeungnam University, Taegu 705-035, South Korea.
- 2Department of Psychiatry College of Medicine, Yeungnam University, Taegu 705-035, South Korea.
- 3Department of Pharmacology, College of Medicine, Kyungpook National University, Taegu 700-412, South Korea.
- 4Department of Psychiatry, College of Medicine, Dongook University, Kyungjoo, Kyungpook Province 305-606, South Korea.
Abstract
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Peripheral benzodiazepine receptor(PBR) has been identified in various
peripheral tissues including kidney. The physiological and
pharmacological functions of PBR are still uncertain, although it has
been suggested that these are associated with the regulation of
stress/anxiety response. Diazepam progeny, which were exposed to
diazepam perinatally, was reported to be an animal model of chronic
anxiety. However, PBR in the diazepam progenies are not known yet. In
the present study, therefore, we examined the changes of PBR in the
stress/anxiety response. Dams of rats were given injection of diazepam
or vehicle during puerperium. Diazepam progenies showed increased level
of anxiety on the performance of elevated plus maze, and increased Bmax
of PBR. Saturation experiments followed by scatchard analysis of the
results
showed that the increase in the density of PBR and the affinity of the PBR remained unchanged. Forced swim stress increased anxiety on the plus maze in both groups of rats. In contrast to control, diazepam progenies did not show further upregulation of renal PBR immediately after swimming stress, but still higher than control. From the above
results
, it may be concluded that upregulation of renal PBR is associated with chronic anxiety as well as stress-induced response.
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