Korean J Immunol.  1997 Dec;19(4):571-582.

Immunological Activities of Korean Mistletoe Extract ( Viscum album coloratum ; KM - 110 )

• Kim JB
• Yoon TJ
• Yoo YC
• Kang TB
• Do MS
• Azuma I

Abstract

Immunological effect of the extract (KM-110) from Korean mistletoe (Viscum album coloratum) was examined. Lymphocytes obtained from KM-110-administrated mice showed increased responsiveness to mitogens, concanavalin-A (Con.A) and lipopolysaccharide (LPS). In order to study cytokine induct ability of the KM-110, macrophages from the Balb/c mice were cultivated in the medium containing the extract. the macrophages were shown to induce secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin 1 and 6 (IL-1, IL-6) and interferon-gamma (INF-gamma). We then tested antitumor activity of the macrophages activated by the KM-110. Peritoneal macrophages harvested from the KM110-treated Balb/c mice exhibited cytotoxicity against the syngeneic 3LL carcinoma cells. ...continue...

Keyword

Viscum album coloratum; Macrophage; Tumor vaccine; Adjuvant

MeSH Terms

Animals
Interferon-gamma
Interleukin-1
Lymphocytes
Macrophages
Macrophages, Peritoneal
Mice
Mistletoe*
Mitogens
Tumor Necrosis Factor-alpha
Viscum album*
Viscum*
Interferon-gamma
Interleukin-1
Mitogens
Tumor Necrosis Factor-alpha