- Neoadjuvant and Adjuvant Treatments for Resectable and Borderline Resectable Pancreatic Ductal Adenocarcinoma: The Current Status of Pancreatic Ductal Adenocarcinoma Treatment in Japan
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Ei S, Takahashi S, Ogasawara T, Mashiko T, Masuoka Y, Nakagohri T
- KMID: 2546012
- Gut Liver.
- 2023 Sep;17(5):698-710.
- doi: 10.5009/gnl220311
Resection is the only curative treatment for pancreatic ductal adenocarcinoma (PDAC). Although the outcome of technically resectable PDAC has improved with advances in surgery and adjuvant therapy, the 5-year survival... -
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- Can chemotherapy be omitted for patients with N0 or N1 endocrine-sensitive breast cancer treated with gonadotropin-releasing hormone agonist and tamoxifen?
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Lee J, Park CS, Oh JH, Park IC, Seong MK, Noh WC, Kim HA
- KMID: 2544610
- Ann Surg Treat Res.
- 2023 Jul;105(1):31-36.
- doi: 10.4174/astr.2023.105.1.31
Purpose: Whether administering chemotherapy followed by tamoxifen plus a gonadotropin-releasing hormone (GnRH) agonist to treat patients with lower-risk hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer... -
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- Survival Benefit of Adjuvant Chemotherapy in Patients with Pancreatic Ductal Adenocarcinoma Who Underwent Surgery Following Neoadjuvant FOLFIRINOX
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Lee SH, Hwang DW, Yoo C, Kim Kp, Kang S, Jeong JH, Oh D, Song TJ, Lee SS, Park DH, Seo DW, Park Jh, Song KB, Lee JH, Lee W, Park Y, Kwak BJ, Chang HM, Ryoo BY, Kim SC
- KMID: 2544176
- Cancer Res Treat.
- 2023 Jul;55(3):956-968.
- doi: 10.4143/crt.2022.409
Purpose The benefit of adjuvant chemotherapy following curative-intent surgery in pancreatic ductal adenocarcinoma (PDAC) patients who had received neoadjuvant FOLFIRINOX is unclear. This study aimed to assess the survival benefit... -
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- Impact of Nrf2 overexpression on cholangiocarcinoma treatment and clinical prognosis
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Lee H, Min SK, Cho MS, Lee HK
- KMID: 2543960
- Korean J Clin Oncol.
- 2023 Jun;19(1):18-26.
- doi: 10.14216/kjco.23004
Purpose: Nrf2 regulates antioxidant protein expression and protects against drug toxicity and oxidative stress, whereas Keap1 controls Nrf2 activity. The Keap1-Nrf2 pathway affects the prognosis of various cancers, however, its... -
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- Protective Efficacy and Immunogenicity of Rv0351/Rv3628 Subunit Vaccine Formulated in Different Adjuvants Against Mycobacterium tuberculosis Infection
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Kwon KW, Kang TG, Lee A, Jin SM, Lim YT, Shin SJ, Ha SJ
- KMID: 2544669
- Immune Netw.
- 2023 Apr;23(2):e16.
- doi: 10.4110/in.2023.23.e16
Bacillus Calmette-Guerin (BCG) vaccine is the only licensed vaccine for tuberculosis (TB) prevention. Previously, our group demonstrated the vaccine potential of Rv0351 and Rv3628 against Mycobacterium tuberculosis (Mtb) infection by... -
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- Adjuvant treatment for resectable non-small cell lung cancer
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Lim JU
- KMID: 2541445
- J Korean Med Assoc.
- 2023 Mar;66(3):173-179.
- doi: 10.5124/jkma.2023.66.3.173
Background: Low-dose chest computed tomography is being increasingly used to screen for lung cancer, and the proportion of early diagnoses of patients with lung cancer in potentially resectable stages is... -
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- Dancing with the Surgeon: Neoadjuvant and Adjuvant Immunotherapies from the Medical Oncologist’s Perspective
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Park S
- KMID: 2540068
- J Chest Surg.
- 2023 Mar;56(2):67-74.
- doi: 10.5090/jcs.23.009
Perioperative treatment with conventional cytotoxic chemotherapy for resectable nonsmall cell lung cancer (NSCLC) has proven clinical benefits in terms of achieving a higher overall survival (OS) rate. With its success... -
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- Can clinicopathologic high-risk features in T3N0 colon cancer be reliable prognostic factors?
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Lee HG, Kim YI, Park IJ, Lim SB, Yu CS
- KMID: 2539225
- Ann Surg Treat Res.
- 2023 Feb;104(2):109-118.
- doi: 10.4174/astr.2023.104.2.109
Purpose: The purpose of this study was to assess the reliability and prognostic significance of the high-risk feature (HRF) in patients with T3N0 colon cancer. Methods: We included 1,205 patients with... -
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- Pancreatoduodenectomy following neoadjuvant chemotherapy in duodenal adenocarcinoma
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Seo D, Park BG, Jung D, Hwang HK, Kim SH, Hong SS, Kang CM
- KMID: 2539522
- Ann Hepatobiliary Pancreat Surg.
- 2023 Feb;27(1):114-119.
- doi: 10.14701/ahbps.22-069
A 51-year-old male patient had four times of massive hematochezia episode three days before arrival. Carbohydrate antigen (CA) 19-9 level was extremely elevated. Computed tomography, magnetic resonance imaging, and positron... -
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- Benefits of Adjuvant Chemotherapy for Clinical T3-4N0 Rectal Cancer After Preoperative Chemoradiotherapy
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Bang HJ, Shim HJ, Hwang JE, Bae WK, Chung IJ, Cho SH
- KMID: 2538699
- Chonnam Med J.
- 2023 Jan;59(1):76-82.
- doi: 10.4068/cmj.2023.59.1.76
While the guidelines for adjuvant chemotherapy (AC) for colon cancer are relatively standardized, those for early rectal cancer are still lacking. We therefore evaluated the role of AC in clinical... -
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- Role of Adjuvant Radiotherapy in Gastric Cancer
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Yu JI
- KMID: 2539474
- J Gastric Cancer.
- 2023 Jan;23(1):194-206.
- doi: 10.5230/jgc.2023.23.e1
Although continuous improvement in the treatment outcome of localized gastric cancer has been achieved through early screening, diagnosis, and treatment and the active application of surgery and adjuvant chemotherapy, the... -
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- Update on Adjuvant Treatment in Resectable Non-Small Cell Lung Cancer and Potential Biomarkers Predicting Postoperative Relapse
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Lim JU
- KMID: 2537199
- Tuberc Respir Dis.
- 2023 Jan;86(1):14-22.
- doi: 10.4046/trd.2022.0081
A significant proportion of patients with non-small cell lung cancer (NSCLC) is diagnosed in the early and resectable stage. Despite the use of platinum-based adjuvant chemotherapy, there was only a... -
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- The Role of Adjuvant Therapy Following Surgical Resection of Small Cell Lung Cancer: A Multi-Center Study
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Park SY, Park S, Lee GD, Kim HK, Choi S, Kim HR, Kim YH, Kim DK, Park SI, Hong TH, Choi YS, Kim J, Cho JH, Shim YM, Zo JI, Na KJ, Park IK, Kang CH, Kim YT, Park BJ, Lee CY, Lee JG, Kim DJ, Paik HC
- KMID: 2537995
- Cancer Res Treat.
- 2023 Jan;55(1):94-102.
- doi: 10.4143/crt.2022.290
Purpose This multi-center, retrospective study was conducted to evaluate the long-term survival in patients who underwent surgical resection for small cell lung cancer (SCLC) and to identify the benefit of... -
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- The effect and therapeutic compliance of adjuvant therapy in patients with cholangiocarcinoma after R0 resection: a retrospective study
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Jeong HT, Lee J, Jo HH, Kim HG, Han J
- KMID: 2538787
- J Yeungnam Med Sci.
- 2023 Jan;40(1):65-77.
- doi: 10.12701/jyms.2022.00213
Background: This study aimed to compare clinical outcomes between surveillance and adjuvant therapy (AT) groups after R0 resection for cholangiocarcinoma (CCA). Methods: A total of 154 patients who underwent R0... -
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- Extended Chemotherapy Followed by Staged Bilateral Nephron Sparing Surgery in Advanced Bilateral Wilms Tumor: Individualising Treatment Options for Optimal Outcome
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Karagiri MR, Malik K, Radhakrishnan V, Raja A
- KMID: 2538291
- Adv Pediatr Surg.
- 2022 Dec;28(2):65-69.
- doi: 10.13029/aps.2022.28.2.65
Approximately 5% of Wilms tumors are bilateral. Multidisciplinary care including surgery, chemotherapy, and radiation has greatly improved the survival rates. With long-term survivorship, treatment should be planned to ensure quality... -
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- Anaplastic Meningioma: Clinical Characteristics, Prognostic Factors and Survival Outcome
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Seo DO, Song SW, Kim YH, Hong CK, Kim JH
- KMID: 2534723
- Brain Tumor Res Treat.
- 2022 Oct;10(4):244-254.
- doi: 10.14791/btrt.2022.0030
Background Anaplastic meningioma is very rare and is generally known to have a poor prognosis. However, due to its rarity, the relationship between clinical prognosis and prognostic factors is not clear.... -
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- Neoadjuvant chemoradiotherapy determines the prognostic impact of anastomotic leakage in advanced rectal cancer
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Oh BY, Park YA, Huh JW, Cho YB, Yun SH, Kim HC, Lee WY
- KMID: 2534128
- Ann Surg Treat Res.
- 2022 Oct;103(4):235-243.
- doi: 10.4174/astr.2022.103.4.235
Purpose: The prognostic impact of anastomotic leakage (AL) in rectal cancer remains uncertain. We investigated the prognostic significance of AL in rectal cancer patients who underwent curative surgery, especially in... -
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- Adjuvant Imatinib Treatment for 5 Years versus 3 Years in Patients with Ruptured Localized Gastrointestinal Stromal Tumor: A Retrospective Analysis
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Kang S, Ryu MH, Bang YH, Kim HD, Lee HE, Kang YK
- KMID: 2534196
- Cancer Res Treat.
- 2022 Oct;54(4):1167-1174.
- doi: 10.4143/crt.2021.1040
Purpose Three years of adjuvant imatinib is the standard treatment for resected gastrointestinal stromal tumors (GISTs) with rupture, but the recurrence rate is prominently high. We aimed to investigate the... -
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- Neoadjuvant and Adjuvant Chemotherapy for Cholangiocarcinoma
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Lee HS
- KMID: 2532496
- Korean J Pancreas Biliary Tract.
- 2022 Jul;27(3):111-115.
- doi: 10.15279/kpba.2022.27.3.111
Cholangiocarcinoma consists of a heterogeneous group of aggressive and rare malignancies that arise from the bile ducts outside or inside the liver. Although surgical resection remains the only potential curative... -
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- Apurinic/apyrimidinic endonuclease 1 is associated with poor prognosis after curative resection followed by adjuvant chemotherapy in patients with stage III colon cancer
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Song JH, Lee MS, Cha EY, Lee KH, Kim JY, Kim JS
- KMID: 2531831
- Korean J Clin Oncol.
- 2022 Jun;18(1):1-10.
- doi: 10.14216/kjco.22001
Purpose: Apurinic/apyrimidinic endonuclease 1 (APE1) is a key enzyme involved in the base excision repair pathway. It also has redox activity and maintains various transcription factors in an active reduced... -
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