Korean J Dermatol.  1999 Mar;37(3):290-296.

The Expression of Keratinocyte Growth Factor mRNA in Dendritic Epidermal T Cell

Abstract

BACKGROUND: The keratinocyte growth factor(KGF) is a recently identified mitogen for epithelial cells produced by nomal stromal fibroblasts. ln the skin, KGF has been shown to stimulate keratinocyte proliferation and differentiatian. Dendritic epidermal T cells(DETC) are skin-specific members of the epithelial y 8 T-cell family that reside normally in the murine epidermis. The DETCs recognize antigen expressed by damaged or diseased neighboring keratinoctyes and consequently secrete cytokines sueh as IFN- y, lL-2, IL-4, GM-CSF.
OBJECTIVE
The purpose of this study was to observe the expression of KGF mRNA in keratinocyte and DETC as well as to investigate the cytokine-mediated intercellular communication between kerati- nocyte and DETC.
METHODS
Using a RT-PCR(reverse transcription-polymerase chain reaction), we examined the expression of KGF mRNA in keratinocyte and DETC, and compared the level of KGF mRNA between resting and activated DETC with Con-A (concanavalin A).

Keyword

Dendritic epidermal T cell; Keratinocyte growth factor

MeSH Terms

Cytokines
Epidermis
Epithelial Cells
Fibroblast Growth Factor 7*
Fibroblasts
Granulocyte-Macrophage Colony-Stimulating Factor
Humans
Interleukin-4
Keratinocytes*
RNA, Messenger*
Skin
T-Lymphocytes
Cytokines
Fibroblast Growth Factor 7
Granulocyte-Macrophage Colony-Stimulating Factor
Interleukin-4
RNA, Messenger
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