J Korean Ophthalmol Soc.  1995 Dec;36(12):2121-2128.

Detection of Epidermal Growth Factor Receptor mRNA by in Situ Hybridization in Cataractous Lens Epithelium

• Kim JC
• Bae GJ
• Kim JH

Abstract

In this study, we investigated the correlation between the expression of EGFR-mRNA in situ hybridization method and the clinical feature of the cataract. The results were as followed. Nineteen out of fourty six cases(41.3%) were showed the expression of EGFRmRNA in lens epithelium. No correlation between the age of the lenses and the expression of EGFR-mRNA could be demonstrated. The expression of EGFR-mRNA in lens epithelium correlated significantly (P<0.01) with the clinical stage of the cataract. No correlation between the diabetes mellitus and the expression of EGFRmRNA could be demonstated. These results suggest that the EGFR-mRNA status in lens epithelium could be important for the development of the cataract.

Keyword

Epidermal growth facter; Epidermal growth facter recepter; In situ hybridization; Cataractous lens epithelium

MeSH Terms

Cataract*
Diabetes Mellitus
Epidermal Growth Factor*
Epithelium*
In Situ Hybridization*
Receptor, Epidermal Growth Factor*
Epidermal Growth Factor
Receptor, Epidermal Growth Factor