J Korean Soc Microbiol.  1999 Oct;34(5):445-452.

Plasmid Profile and B - Lactamase Type of Multidrug - Resistant Salmonella typhi Isolated from Korea, 1997

Abstract

Eight strains of multidrug-resistant (MDR) Salmonella typhi were isolated from Kyonggi area during January-February,1997. They were resistant to ampiciUin, amoxicillin, carbeniciillin, tetracycline, chloramphenicol, trimethoprim/sulfamethoxazole, trimethoprim. Eight strains had one plasmid respectively which size was approximately M.W 220 kb and showed same restriction pattern by endonuclease HindIII. The plasmid was similar to the plasmid in size that was related to multidrug resistant S. typhi isolated from southeast Asia. It were transferred by conjugation to recipient E, coli K-12 in frequency of 2.43 x10-4 - 1.73 x 10-2 and transconjugant showed same drug-resistant pattem with donor cells. All of 8 strains produced B-lactamase that was assummed to TEM-1 type by isoelectric focusing and PCR.

Keyword

Salmonella typhi; Multidrug-resistant; Plasmid; B-lactamase

MeSH Terms

Amoxicillin
Asia, Southeastern
Chloramphenicol
Deoxyribonuclease HindIII
Gyeonggi-do
Humans
Isoelectric Focusing
Korea*
Plasmids*
Polymerase Chain Reaction
Salmonella typhi*
Salmonella*
Tetracycline
Tissue Donors
Trimethoprim
Amoxicillin
Chloramphenicol
Deoxyribonuclease HindIII
Tetracycline
Trimethoprim
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