J Korean Soc Microbiol.
1997 Apr;32(2):175-181.
Selection of vaccine candidate from Salmonella typhi isolated in Korea
- Affiliations
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- 1Laboratory of Molecular Bacteriology, National Institute of Health, Seoul, School of Life Sciences, Chungbuk Nat. University, Korea.
- 2Division of Microbiology, Hannam University, Korea.
Abstract
- Vaccine cadidate strains were selected through tests of minimal media, antibiotic susceptibility patterns, plasmid profiles and mouse virulence from 120 Salmonella typhi strains, which were collected from university hospital in Korea. For the production of deleted gene mutants, first of all, we have selected 37 strains growth on minimal media and have selected KNIH 352 among the 37 strains by antibiotic susceptibility patterns and virulence tests. In the antibiotic susceptibility tests, isolated strains have appeared lower antibiotics resistance frequency than other enteric bacteria. In plasmid pattern, all of isolated strains except KNIH 352 strain have showed one band, approximately 24 Kb plasmid. But, only KNIH 352 strain has showed various plasmid patterns and the high toxicity in virulence test.
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