J Korean Soc Microbiol.
1997 Apr;32(2):167-174.
Primary Isolate S-352, a Novel Clone of Salmonella typhi, shows Strong Viability in Macrophage
- Affiliations
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- 1Department of Microbiology, Hannam University, Daejeon, Korea.
- 2Food Irradiation Division, Korea Atomic Energy Reach Institute, Korea.
- 3Laboratory of Molecular Bacteriology, National Institute of Health, Korea.
- 4School of Life Science, Chungbuk University, Korea.
Abstract
- In order to develop a multivalent vaccine from a primary isolate against enteric bacterial diseases, several candidates were selected from the recent enteric patients in Korea. Among the 120 pathogenic Salmonella typhi patients' isolates, two highly virulent clones, S-100 and S-352, were finally selected through a series of selection procedures like colony morphology, growth rate in minimal media, Lethal Dose 50, antibiotic-sensitivity, plasmid analysis, mouse protection assay, agglutination test, and so on. These two virulent clones were tested for their macrophage sensitivity and antigenic compositions together with other standard enteric bacteria. In this report, we address that the S-352 is a new clone which is different from any standard strains of Salmonella and Shigella in antigenic composition. Particular noteworthy is that S-352 is much more resistant to primary macrophages than Salmonella typhi wild type Ty2, suggesting that it will become a good vaccine candidate when manipulated by knocking-out of virulent genes.
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