Korean J Anat.  1999 Dec;32(6):775-778.

Expression of protein kinase C-gamma mRNA on the spinal cord in a rat model of neuropathic pain

• Rhyu IJ
• Na HS
• Sung B
• Kang YH
• Kim H
• Suh YS

Abstract

Partial peripheral nerve injury occasionally results in neuropathic pain, including spontaneous burning pain and increased sensitivity to sensory stimuli such as hyperalgesia and allodynia. The pathophysiological mechanisms underlying this disease are poorly understood and the available treatments unsatisfactory. Presently, the neuropathic pain is believed to result from an increase in the excitability of the dorsal horn neurons (central sensitization), which is induced by abnormal signals from injured afferents. PKC-gamma is known to play a pivotal role in central sensitization following peripheral nerve injury. In the present study, we examine the expression of PKC-gamma mRNA of the spinal dorsal horn after neuropathic injury. There was no significant difference of PKC-gamma mRNA between lesion and control sides. These results suggest that PKC-gamma mRNA is not a key factor for the generation of neuropathic pain.

Keyword

Neuropathic pain; PKC-gamma; Dorsal horn of spinal cord

MeSH Terms

Animals
Burns
Central Nervous System Sensitization
Horns
Hyperalgesia
Models, Animal*
Neuralgia*
Peripheral Nerve Injuries
Posterior Horn Cells
Protein Kinases*
Rats*
RNA, Messenger*
Spinal Cord*
Protein Kinases
RNA, Messenger