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Spinal Nitric Oxide Synthase Type II Increases Neurosteroid-metabolizing Cytochrome P450c17 Expression in a Rodent Model of Neuropathic Pain

Choi SR, Beitz AJ, Lee JH

We have previously demonstrated that the neurosteroid dehydroepiandrosterone sulfate (DHEAS) induces functional potentiation of N-methyl-D-aspartate (NMDA) receptors via increases in phosphorylation of NMDA receptor GluN1 subunit (pGluN1). However, the modulatory...
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Potential Mechanisms Underlying the Increased Excitability of the Bladder Afferent Pathways in Interstitial Cystitis/Bladder Pain Syndrome

Kim DS

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic debilitating disorder associated with lower urinary tract symptoms, including frequency, urgency, and suprapubic pain, which inconveniences the patients and seriously impairs their...
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Effects of applying nerve blocks to prevent postherpetic neuralgia in patients with acute herpes zoster: a systematic review and meta-analysis

Kim HJ, Ahn HS, Lee JY, Choi SS, Cheong YS, Kwon K, Yoon SH, Leem JG

BACKGROUND: Postherpetic neuralgia (PHN) is a common and painful complication of acute herpes zoster. In some cases, it is refractory to medical treatment. Preventing its occurrence is an important issue....
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New Era of Post Urinary Tract Infection Pain Syndrome

Lee KW, Kim YH

Urinary tract infection (UTI) in most cases is accompanied by pain. However, in some cases, including asymptomatic bacteriuria (ASB), pain is absent and thus, cannot be characterized. A study with...
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Chronic Refractory Cough

Kim SK

Chronic refractory cough is defined as a cough that persists despite guideline based treatment. It is seen in 20-46% of patients presenting to specialist cough clinics and it has a...
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Mechanisms of postoperative pain

Kang S, Brennan TJ

Good pain control after surgery is important to facilitate overall recovery, improve patient satisfaction, decrease morbidity, and reduce health care cost. However, despite heightened awareness and development of new guidelines...
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The effect of preemptive intravenous ketamine on postoperative pain in patients undergoing arthroscopic rotator cuff repair with intra articular ropivacaine injection

Hong EP, Jeong DH, Kang HY, Choi JH, Park SW

BACKGROUND: A low dose of ketamine can be an effective preemptive analgesic by preventing central sensitization when administered before surgical trauma. In this study, we assessed the preemptive analgesic effect...
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Neuropathic Pain in Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)

Lee SJ

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) has been a frustrating condition that is characterized by pain in areas including the perineum, rectum, prostate, penis, testicles, and abdomen. Unfortunately, effective treatment...
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Effect of intraoperative infusion of ketamine on remifentanil-induced hyperalgesia

Choi E, Lee H, Park HS, Lee GY, Kim YJ, Baik HJ

BACKGROUND: Opioid induced hyperalgesia (OIH) is related with high opioid dosage, a long duration of opioid administration, and abrupt discontinuation of infused opioids in anesthetic settings. Ketamine is known to...
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The Role of Central Sensitization in Chronic Pain of Rheumatic Diseases

Lee HS

Pain is the most common symptom of almost all rheumatic diseases such as rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, osteoarthritis, fibromyalgia, and others. In addition to commonly known peripheral...
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Attenuated Glial K+ Clearance Contributes to Long-Term Synaptic Potentiation Via Depolarizing GABA in Dorsal Horn Neurons of Rat Spinal Cord

Lee J, Favorov OV, Tommerdahl M, Lee CJ, Whitsel BL

It has been reported that long-term enhancement of superficial dorsal horn (DHs) excitatory synaptic transmission underlies central sensitization, secondary hyperalgesia, and persistent pain. We tested whether impaired clearance of K+...
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The effect of ketamine as an additive in epidural block on the intractable herpetic neuralgia: a case report

Lee JY, Sim WS, Kim KM, Oh MS, Lee JE

Ketamine has been shown to have analgesic effect by blocking N-methyl-D-aspartate receptor, thus preventing and reducing central sensitization caused by peripheral nociceptive stimulation. However, due to lack of knowledge about...
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Antiallodynic effects of vitamin C and vitamin E in chronic post-ischemia pain rat model

Park JM, Kim CK, Lee HC, Jung H, Choi KU, Hong SW, Lim DG, Baek WY, Kwak KH

BACKGROUND: Recent research has shown that reactive oxygen species (ROS) play a significant role in the development and persistence of neuropathic pain through central sensitization via N-methyl-D-aspartate (NMDA) receptor activation....
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Irritable Bowel Syndrome and Migraine: Bystanders or Partners?

Chang FY, Lu CL

  • KMID: 2326229
  • J Neurogastroenterol Motil.
  • 2013 Jul;19(3):301-311.
Irritable bowel syndrome (IBS) and migraine are distinct clinical disorders. Apart from the characteristics of chronic and recurrent pain in nature, these pain-related disorders apparently share many similarities. For example,...
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Chronic Prostatitis/Chronic Pelvic Pain Syndrome: What Are the Starting and Worsening Factors?

Chung H

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in the absence of any identifiable pathology such as cancer, curable infection, or anatomic abnormalities is defined as "urologic pain or discomfort in the...
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Effects of NaOCl on Neuronal Excitability and Intracellular Calcium Concentration in Rat Spinal Substantia Gelatinosa Neurons

Lee HI, Park AR, Chun SW

  • KMID: 1431123
  • Int J Oral Biol.
  • 2013 Mar;38(1):5-12.
Recent studies indicate that reactive oxygen species (ROS) can act as modulators of neuronal activity, and are critically involved in persistent pain primarily through spinal mechanisms. In this study, we...
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Effect of superoxide on the development and maintenance of mechanical allodynia in a rat model of chronic post-ischemia pain

Han CG, Han JK, Park KB, Kwak KH, Park SS, Lim DG

BACKGROUND: Reactive oxygen species and inflammatory responses contribute to the development of neuropathic pain. Superoxide serves to mediate cell signaling processes and tissue injury during inflammation. We examined the effects...
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Antinociceptive effect of phenyl N-tert-butylnitrone, a free radical scavenger, on the rat formalin test

Ko YK, Youn AM, Hong BH, Kim YH, Shin YS, Kang PS, Yoon KJ, Lee WH

BACKGROUND: Reactive oxygen species (ROS) such as superoxide radicals, hydrogen peroxide, nitric oxide, and nitroperoxide, cause oxidative stress which interferes with normal cell functioning, resulting in cell damage. It is...
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The effect of pulsed radiofrequency (PRF) for the treatment of supraorbital neuropathic pain: A report of three cases

Bae HM, Kim YH, Kim SW, Moon DE

  • KMID: 2169095
  • Anesth Pain Med.
  • 2012 Apr;7(2):117-120.
Historically, peripheral neuropathic pain has occasionally been difficult to treat. Both a systematic review of the evidence as well as clinical experience have demonstrated that treatment options including polypharmacy provide...
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Effects of Mitochondrial Reactive Oxygen Species on Neuronal Excitability in Rat Spinal Substantia Gelatinosa Neurons

Lee HI, Park AR, Chun SW

  • KMID: 2009495
  • Int J Oral Biol.
  • 2012 Mar;37(1):17-23.
Recent studies indicate that reactive oxygen species (ROS) are critically involved in persistent pain primarily through spinal mechanisms, and that mitochondria are the main source of ROS in the spinal...
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