Ann Dermatol.  2007 Sep;19(3):106-111. 10.5021/ad.2007.19.3.106.

Effect of Cyclosporine on Peripheral Blood and Lesional Skin in Psoriatic Patients

• Chang SE
• Yun WJ
• Yoon GS
• Choi JH
• Kim BS
• Hong SJ

• KMID: 1520574
• DOI: http://doi.org/10.5021/ad.2007.19.3.106

Abstract

BACKGROUND: Cyclosporine effectively suppresses immune responses and inhibits skin homing T cell responses in psoriasis. E-selectin is known to be up-regulated on vascular endothelium of inflammatory skin lesions such as psoriasis. PURPOSE: Based on our previous study that cyclosporine decreased lesional cutaneous lymphocyte antigen (CLA)+ T cells in psoriatic patients, we tried to find any change of CLA+ T cells in peripheral blood in psoriatic patients, since psoriasis is a disease of systemic T cell activation.
Subjects and Methods
Peripheral blood of 8 patients with chronic plaque type psoriasis at 0, 3, 6, 12, 18 weeks after cyclosporine was examined by flow cytometry using anti-CLA antibody. Five skin biopsy samples at 0, 3, 6, 12, 18 weeks were immunohistochemically stained with anti E-selectin antibody.
RESULTS
Our results demonstrate that the number of CD3+ CLA+ and CD4+CLA+ T cells was significantly reduced in the peripheral blood at week 3, but gradually increased to the level of baseline at 18 weeks. In psoriatic skin lesions, with decrease of PASI score and CLA+ T cells number, the expression of E-selectin on the endothelial cells was gradually decreased throughout 18 weeks of therapy.
CONCLUSION
These results suggest that cyclosporine suppresses the migration of skin homing T cells to psoriatic skin lesions, in part, through the inhibition of E-selectin on the endothelial cells.

Keyword

Cyclosporine; Psoriasis

MeSH Terms

Biopsy
Cyclosporine*
E-Selectin
Endothelial Cells
Endothelium, Vascular
Flow Cytometry
Humans
Lymphocytes
Psoriasis
Skin*
T-Lymphocytes
Cyclosporine
E-Selectin