Korean J Phys Anthropol.  2013 Dec;26(4):147-153. 10.11637/kjpa.2013.26.4.147.

Podocyte-specific Expression of C1q/TNF-alpha Related Protein 1 in Mice

• Cho KJ
• Yang Y
• Lee YH
• Kim S

• KMID: 1502524
• DOI: http://doi.org/10.11637/kjpa.2013.26.4.147

Abstract

C1q/TNF-alpha Related Protein 1 (CTRP1), an adiponectin paralog, is a novel member of the C1q-TNF Related Protein family. CTRP1 is expressed in the kidney, although its localization and role in the kidney have not been studied. This study examined CTRP1 expression and function in the kidney. CTRP1 immunohistochemistry and PAS staining of the kidneys of C57/BL6 and FGS/Nga mice were performed. In situ hybridization for podocin in the kidney was also performed. CTRP1 immunoreactivity was found only in the glomeruli of the kidney. The CTRP1-immunoreactive cells in the glomeruli were identified as podocytes. The number of CTPR1-immunoreactive cells and the intensity of CTRP1 immunoreactivity were lower in the glomeruli of FGS/Nga mice, which develop progressive proteinuria and focal glomerulosclerosis. CTRP1 is a novel protein expressed in podocytes of the mouse kidney and may have a role in podocytes related to glomerular filtration in the kidney.

Keyword

Podocyte; CTRP1; Glomerulosclerosis; Proteinuria; Glomerular filtration

MeSH Terms

Adiponectin
Animals
Filtration
Glomerulosclerosis, Focal Segmental
Humans
Immunohistochemistry
In Situ Hybridization
Kidney
Mice*
Podocytes
Proteinuria
Adiponectin