Korean J Parasitol.
2011 Jun;49(2):191-194. 10.3347/kjp.2011.49.2.191.
Expression of TNF-alpha and IL-1beta in Splenic Dendritic Cells and Their Serum Levels in Mouse Sparganosis
- Affiliations
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- 1Department of Parasitology and Ewha Global Challenge, School of Medicine, Ewha Womans University, Seoul 158-710, Korea. parayang@ewha.ac.kr
- KMID: 1090623
- DOI: http://doi.org/10.3347/kjp.2011.49.2.191
Abstract
- Sparganosis is a tissue invading helminthiasis infecting intermediate hosts, including humans. Strong immune responses are expected to occur in early phases of infection. Thus, we investigated cytokine expressions in splenic dendritic cells and in sera after experimental infection of mice. In splenic dendritic cells, TNF-alpha and IL-1beta expression peaked at week 1 and week 3 post-infection (PI), respectively, and also early phase (week 2 PI) depressed cytokine expression was noticed. Serum IL-1beta concentration increased significantly at week 2 PI and peaked at week 6 PI, and that of TNF-alpha peaked at week 6 PI. These results showed that pro-inflammatory cytokines, TNF-alpha and IL-1beta, are chronologically regulated in mouse sparganosis.
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