Korean J Gastroenterol.  2013 May;61(5):270-278. 10.4166/kjg.2013.61.5.270.

Clinical Outcome of Treatment with Infliximab in Crohn's Disease: A Single-Center Experience

• Kim YJ
• Kim JW
• Lee CK
• Park HJ
• Shim JJ
• Jang JY
• Dong SH
• Kim HJ
• Kim BH
• Chang YW

• KMID: 1501649
• DOI: http://doi.org/10.4166/kjg.2013.61.5.270

Abstract

BACKGROUND/AIMS
Our aim was to assess the long-term data regarding efficacy and safety of infliximab (IFX) treatment for refractory Crohn's disease (CD) patients in our tertiary teaching hospital.
METHODS
We have retrospectively analyzed the medical records of 89 CD patients who underwent IFX treatment between March 2003 and February 2011 at Kyung Hee University Hospital (Seoul, Korea). The primary outcome measurements were the rates of initial clinical response (CR) at 10 weeks after the 1st IFX infusion and sustained CR at the end of the follow-up. Overall adverse events related to IFX treatment were also evaluated.
RESULTS
The mean (SD) follow-up period of eligible 80 patients was 33.7 (21.9) months. A total of 77 patients (96%) showed initial clinical response, but 8 patients showed loss of response to IFX during the follow-up. Finally, 59 patients (59/77, 76.6%) showed sustained CR at the end of the study. Logistic regression analyses showed that an initial CR at 10 weeks was the independent predictor associated with sustained CR (OR 22.286, 95% CI 2.742-132.717, p=0.001). Overall adverse events reported in 18 patients (18/80, 23.3%), including 3 serious infection (pulmonary tuberculosis and herpes zoster).
CONCLUSIONS
Treatment with IFX was efficacious and relatively safe for refractory CD patients in Korea. An initial CR at 10 weeks was significantly associated with sustained CR.

Keyword

Inflammatory bowel disease; Crohn's disease; Infliximab; Safety

MeSH Terms

Adult
Antibodies, Monoclonal/adverse effects/*therapeutic use
Crohn Disease/*drug therapy
Female
Follow-Up Studies
Gastrointestinal Agents/adverse effects/*therapeutic use
Herpes Zoster/etiology
Humans
Logistic Models
Male
Odds Ratio
Retrospective Studies
Treatment Outcome
Tuberculosis, Pulmonary/etiology
Young Adult
Antibodies, Monoclonal
Gastrointestinal Agents

Figure

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  Fig. 1. Flow chart of the study population. CD, Crohn's disease; IFX, infliximab; TB, tuberculosis.

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  Fig. 2. Clinical response at 10 weeks after the initiation of the infliximab treatment. CD, Crohn's disease.

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  Fig. 3. The sustained clinical and biologic response in patients with Crohn's disease (CD) at the end of follow-up.

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  Fig. 4. The sustained clinical response in patients with Crohn's disease at the end of follow-up stratified by of the disease prior to the infliximab (IFX) treatment (A) and clinical complete response at 10 weeks (B) via Kaplan Meier survival plots. CR, complete response; PR, partial response.

Reference

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