Yeungnam Univ J Med.
2009 Dec;26(2):125-129. 10.12701/yujm.2009.26.2.125.
A Case of Colchicine-Induced Neutropenia in Liver Cirrhosis Patient
- Affiliations
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- 1Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, Korea. hjlee@med.yu.ac.kr
- KMID: 1469809
- DOI: http://doi.org/10.12701/yujm.2009.26.2.125
Abstract
- Colchicine is an alkaloid that has been used for treating acute gouty arthritis, psoriasis, scleroderma and Behcet's syndrome. Colchicine decreased liver fibrosis in rats with carbon tetrachloride induced cirrhosis and in patients with many liver diseases. Therapeutic oral doses of colchicine may cause nausea, vomiting, abdominal pain and diarrhea. The adverse effect of colchicine associated with the dose is bone marrow suppression, and especially neutopenia. Neutropenia has often been reported in patients have taken an overdose of colchicine. We describe a 64-year-old female liver cirrhosis patient with neutropenia that was induced by a therapeutic dose of colchicine.
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