Int J Oral Biol.  2010 Sep;35(3):99-106.

Luteolin Induces the Differentiation of Osteoblasts

Affiliations
  • 1Department of Oral Biochemistry, School of Dentistry, Dankook University, Korea. syko@dku.edu

Abstract

Luteolin is a flavonoid that exists in a glycosylated form in celery and green pepper. Flavonoids possess antioxidant and anti-inflammatory properties and can reduce the expression of key inflammatory molecules in macrophages and monocytes. It has been reported also that some flavonoids have effects on bone metabolism. The effects of luteolin on the function of osteoblasts were investigated by measuring cell viability, alkaline phosphatase activity, type I collagen production, osteoprotegerin secretion, Wnt promoter activity, BMP-2 and Runx2 expression and calcified nodule formation. Luteolin has no effects upon osteoblast viability but induced an increase in alkaline phosphatase activity, type I collagen production and a decrease in osteoprotegerin secretion in these cells. Luteolin treatment also upregulated BMP-2 mRNA expression. These results suggest that luteolin may be a regulatory molecule that facilitates the differentiation of osteoblasts.

Keyword

luteolin; flavonoid; osteoblast; type I collagen; BMP-2; calcified nodule

MeSH Terms

Alkaline Phosphatase
Apium graveolens
Capsicum
Cell Survival
Collagen Type I
Flavonoids
Luteolin
Macrophages
Monocytes
Osteoblasts
Osteoprotegerin
RNA, Messenger
Alkaline Phosphatase
Collagen Type I
Flavonoids
Luteolin
Osteoprotegerin
RNA, Messenger
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