J Korean Surg Soc.  2012 Jan;82(1):45-49. 10.4174/jkss.2012.82.1.45.

Inflammatory myofibroblastic tumor in colon

Affiliations
  • 1Department of Surgery, The Catholic University of Korea School of Medicine, Seoul, Korea. cmcgslee@catholic.ac.kr
  • 2Department of Radiology, The Catholic University of Korea School of Medicine, Seoul, Korea.
  • 3Department of Hospital Pathology, The Catholic University of Korea School of Medicine, Seoul, Korea.
  • 4Department of Internal Medicine, The Catholic University of Korea School of Medicine, Seoul, Korea.

Abstract

Inflammatory myofibroblastic tumor (IMT) is an uncommon mesenchymal solid tumor commonly documented in children and young adults. Here, we report a case of IMT in colon confirmed pathologically after laparoscopic anterior resection. A 35-year-old man presented with anal bleeding after defecation for 2 weeks. Colonoscopy demonstrated a mass with shallow ulceration in the central area and irregular margin accompanied by intact mucosa in the descending colon. Computer tomography showed a well-demarcated and homogenous solitary mass in the descending colon. We performed laparoscopic anterior resection. This case was diagnosed as IMT after microscopic examination. The tumor was composed of a proliferation of spindle-shaped cells arranged in the hyaline material with chronic inflammatory cells, composed mainly of plasma cells and lymphocytes. Immunohistochemically, tumor cells were positive for smooth muscle actin, and vimentin, and negative for desmin, CD117 (c-kit), anaplastic lymphoma kinase-1.

Keyword

Inflammatory myofibroblastic tumor; Colon

MeSH Terms

Actins
Adult
Child
Colon
Colon, Descending
Colonoscopy
Defecation
Desmin
Hemorrhage
Humans
Hyalin
Lymphocytes
Lymphoma
Mucous Membrane
Muscle, Smooth
Myofibroblasts
Plasma Cells
Ulcer
Vimentin
Young Adult
Actins
Desmin
Vimentin
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