- Predictive Significance of KRAS and Tau for Chemoresponse in Advanced Non-Small-Cell Lung Cancer
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Yoo J, Shim BY, Yoo CY, Kang SJ, Lee KY
- KMID: 1472622
- Korean J Pathol.
- 2009 Oct;43(5):435-440.
- doi: 10.4132/KoreanJPathol.2009.43.5.435
BACKGROUND: Taxane-platinum combinations are often used as first-line treatments for patients with advanced non-small cell lung cancer (NSCLC). Response to chemotherapy for these patients is still poor. The aim of... -
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- Clinical and Pathological Characteristics of Frontotemporal Lobar Degeneration(FTLD) and Molecular Genetics of Tau Protein
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Woo SI
- KMID: 2202778
- J Korean Soc Biol Psychiatry.
- 2003 Nov;10(2):97-106.
Criticisms about amyloid cascade hypothesis of Alzheimer's disease(AD) are based on the findings, first, that the degree of dementia does not correlate with the number of plaques, and second, that... -
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- Microtubule-Associated Protein Tau, alpha-Tubulin and betaIII-Tubulin Expression in Breast Cancer
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Im S, Yoo C, Jung JH, Jeon YW, Suh YJ, Lee YS, Choi HJ
- KMID: 2012154
- Korean J Pathol.
- 2013 Dec;47(6):534-540.
BACKGROUND: The microtubule-associated protein Tau binds to both inner and outer surfaces of microtubules, leading to tubulin assembly and microtubule stabilization. The aim of this study was to evaluate the... -
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- Regulatory B Subunits of Protein Phosphatase 2A Are Involved in Site-specific Regulation of Tau Protein Phosphorylation
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Yu UY, Yoo BC, Ahn JH
- KMID: 2285505
- Korean J Physiol Pharmacol.
- 2014 Apr;18(2):155-161.
- doi: 10.4196/kjpp.2014.18.2.155
Overexpression of amyloid precursor protein with the Swedish mutation causes abnormal hyperphosphorylation of the microtubule-associated protein tau. Hyperphosphorylated isoforms of tau are major components of neurofibrillary tangles, which are histopathological... -
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- Tau Positron Emission Tomography Imaging in Degenerative Parkinsonisms
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Lyoo CH, Cho H, Choi JY, Ryu YH, Lee MS
- KMID: 2405197
- J Mov Disord.
- 2018 Jan;11(1):1-12.
- doi: 10.14802/jmd.17071
In recent years, several radiotracers that selectively bind to pathological tau proteins have been developed. Evidence is emerging that binding patterns of in vivo tau positron emission tomography (PET) studies... -
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- Misfolded Proteins in Neurodegenerative Dementias: Molecular Mechanisms
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Yang HD, Ho DH, Yi MJ, Seol W, Kim SY
- KMID: 2172233
- Dement Neurocogn Disord.
- 2012 Jun;11(2):38-52.
- doi: 10.12779/dnd.2012.11.2.38
During recent years, there has been remarkable progress with respect to the identification of molecular mechanisms and underlying pathology of neurodegenerative dementias. The latest evidence indicates that a common cause... -
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- The Effect of Acetylcholine Esterase Inhibitor on Cerebrospinal Fluid beta-Amyloid 1-42 and Phosphorylated Tau Protein in Korean Alzheimer's Disease Patients: Preliminary Study
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Lee EH, Youn YC, Park KY, Min JH, Kwon OS, Lee HO, Hong HJ
- KMID: 2185066
- J Korean Neurol Assoc.
- 2008 Aug;26(3):224-230.
BACKGROUND: Alzheimer's disease (AD) is characterized by the pathology of amyloid plaques and tau-associated neurofibrillary tangles. Acetylcholine esterase (AChE) transforms the beta-amyloid monomer into an oligomer, and increases beta-amyloid aggregation... -
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- Longitudinal Clinical Changes of Non-Fluent/Agrammatic Primary Progressive Aphasia as Tau Spectrum Disorder: A Case Report
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Kim JS, Jang JW, Kim SH, Wang MJ, Park YH, Kim S
- KMID: 2443007
- Dement Neurocogn Disord.
- 2015 Jun;14(2):87-93.
- doi: 10.12779/dnd.2015.14.2.87
BACKGROUND: Tauopathies are a group of diseases caused by the accumulation of hyperphosphorylated tau protein in the central nervous system. Previous studies have revealed that there is considerable overlap in... -
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- Analysis of Tau Protein Expression in Predicting Pathological Complete Response to Neoadjuvant Chemotherapy in Different Molecular Subtypes of Breast Cancer
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Lei C, Yang C, Xia B, Ji F, Zhang Y, Gao H, Xiong Q, Lin Y, Zhuang X, Zhang L, Zhu T, Cheng M, Yang M, Wang K
- KMID: 2470881
- J Breast Cancer.
- 2020 Feb;23(1):47-58.
- doi: 10.4048/jbc.2020.23.e11
PURPOSE: Tau is a microtubule-associated protein that can be found in both normal and abnormal breast cells. Whether the expression of Tau protein can predict the response to neoadjuvant chemotherapy... -
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- Alzheimer's Disease Diagnosis Using Misfolding Proteins in Blood
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Lee H, Ugay D, Hong S, Kim Y
- KMID: 2471931
- Dement Neurocogn Disord.
- 2020 Mar;19(1):1-18.
- doi: 10.12779/dnd.2020.19.1.1
Alzheimer's disease (AD) is pathologically characterized by a long progressive phase of neuronal changes, including accumulation of extracellular amyloid-β (Aβ) and intracellular neurofibrillary tangles, before the onset of observable symptoms.... -
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- Development of tau PET Imaging Ligands and their Utility in Preclinical and Clinical Studies
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Choi Y, Ha S, Lee YS, Kim YK, Lee DS, Kim DJ
- KMID: 2407298
- Nucl Med Mol Imaging.
- 2018 Feb;52(1):24-30.
- doi: 10.1007/s13139-017-0484-7
The pathological features of Alzheimer's disease are senile plaques which are aggregates of β-amyloid peptides and neurofibrillary tangles in the brain. Neurofibrillary tangles are aggregates of hyperphosphorylated tau proteins, and... -
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- Diverse Molecular Targets for Therapeutic Strategies in Alzheimer's Disease
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Han SH, Mook-Jung
- KMID: 1789947
- J Korean Med Sci.
- 2014 Jul;29(7):893-902.
- doi: 10.3346/jkms.2014.29.7.893
Alzheimer's disease (AD) is the most common form of dementia caused by neurodegenerative process and is tightly related to amyloid beta (Abeta) and neurofibrillary tangles. The lack of early diagnostic... -
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- Olfaction and Neurodegenerative Disease
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Kim HY
- KMID: 2284351
- Hanyang Med Rev.
- 2014 Aug;34(3):116-119.
- doi: 10.7599/hmr.2014.34.3.116
Olfactory dysfunction is an early and common symptom of many neurodegenerative diseases, particularly of Parkinson's disease, Alzheimer's disease, and mild cognitive impairment that heralds progression to dementia. Olfactory impairment is... -
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- Changes of Cytoskeletal System in Neurodegenerative Disease: Immunohistochemical Characterization of Neurofibrillary Changes Induced by Mitotic Spindle Inhibitors
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Koo H
- KMID: 1965100
- Ewha Med J.
- 1992 Mar;15(1):1-9.
- doi: 10.12771/emj.1992.15.1.1
In experimental neurogenerative diseases, aluminum(Al) intoxication and axotomized sensory neurons showed an abnormal accumulation of neurofilaments(NF) in the neuronal perikarya. These NF contain phosphorylated(ph) epitopes that are not detectable in... -
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- The Novel Implication of Androgen in Diabetes-induced Alzheimer's Disease
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Song J, Jung C, Kim OY
- KMID: 2401108
- J Lipid Atheroscler.
- 2017 Dec;6(2):66-74.
- doi: 10.12997/jla.2017.6.2.66
Alzheimer's disease (AD) is characterized by the accumulation of amyloid beta (Aβ) and the hyperphosphorylation of tau protein in the brain, leading to the increase in inflammation and neuronal loss.... -
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- Quantitative Proteomic Analysis Reveals Impaired Axonal Guidance Signaling in Human Postmortem Brain Tissues of Chronic Traumatic Encephalopathy
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Bi B, Choi HP, Hyeon SJ, Sun S, Su N, Liu Y, Lee J, Kowall NW, McKee AC, Yang JH, Ryu H
- KMID: 2451072
- Exp Neurobiol.
- 2019 Jun;28(3):362-375.
- doi: 10.5607/en.2019.28.3.362
Chronic traumatic encephalopathy (CTE) is a distinct neurodegenerative disease that associated with repetitive head trauma. CTE is neuropathologically defined by the perivascular accumulation of abnormally phosphorylated tau protein in the... -
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- Mechanisms of Alzheimer's Disease Pathogenesis and Prevention: The Brain, Neural Pathology, N-methyl-D-aspartate Receptors, Tau Protein and Other Risk Factors
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Kocahan S, DoÄŸan Z
- KMID: 2367656
- Clin Psychopharmacol Neurosci.
- 2017 Feb;15(1):1-8.
- doi: 10.9758/cpn.2017.15.1.1
The characteristic features of Alzheimer's disease (AD) are the appearance of extracellular amyloid-beta (Aβ) plaques and neurofibrillary tangles in the intracellular environment, neuronal death and the loss of synapses, all... -
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- Atypical Early-Onset Alzheimer's Disease Dementia Diagnosed by Biomarker Study
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Lee SK, Shin DS, Shin HS, Kim JH, Park SA
- KMID: 2442935
- Dement Neurocogn Disord.
- 2015 Dec;14(4):168-171.
- doi: 10.12779/dnd.2015.14.4.168
BACKGROUND: The described clinical characteristics of early-onset Alzheimer's disease (EOAD) are distinct from that of late-onset AD. We reported a patient with atypical EOAD. CASE REPORT: A 54-year-old, truck driver developed... -
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- Purification and Identification of Ubiquitin Binding Proteins from Erythrocytes of Patients with Dementia
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Kim HS, Cheon JS, Oh BH, Lee SJ
- KMID: 2186206
- J Korean Geriatr Psychiatry.
- 2003 Jun;7(1):57-66.
OBJECTIVE: The continuous synthesis and degradation of proteins in the cell are essential for the maintenance of cellular homeostasis. Intracellular protein degradation largely occurs in the lysosome and cytoplasm. The... -
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- Real-Time Quaking-Induced Conversion Analysis for the Diagnosis of Sporadic Creutzfeldt-Jakob Disease in Korea
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Park JH, Choi YG, Lee YJ, Park SJ, Choi HS, Choi KC, Choi EK, Kim YS
- KMID: 2364926
- J Clin Neurol.
- 2016 Jan;12(1):101-106.
- doi: 10.3988/jcn.2016.12.1.101
BACKGROUND AND PURPOSE: The level of 14-3-3 protein in the cerebrospinal fluid (CSF) is increased in Creutzfeldt-Jakob disease (CJD) patients, which has led to it being used as a clinical... -
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