J Korean Soc Biol Psychiatry.  2003 Nov;10(2):97-106.

Clinical and Pathological Characteristics of Frontotemporal Lobar Degeneration(FTLD) and Molecular Genetics of Tau Protein

• Woo SI

Abstract

Criticisms about amyloid cascade hypothesis of Alzheimer's disease(AD) are based on the findings, first, that the degree of dementia does not correlate with the number of plaques, and second, that the neurofibrillary tangle formation seems to predate plaque formation. In addition, neurofibrillary tangle counts correlate well with the degree of cognitive impairment. These findings suggest the independent importance of tau abnormality in AD research which is involved in the neurofibrillary tangle formation. Recently, tau pathology without amyloid deposits and mutations in tau protein gene were reported to be the major pathogenic mechanism in Pick's disease, progressive supranuclear palsy, corticobasal degeneration and FTDP-17(frontotemporal dementia and parkinsonism linked with chromosome 17). These data suggest that understanding the causes and consequences of tau dysfunction might give new clinical and therapeutic solutions to many known tauopathies.

MeSH Terms

Amyloid
Dementia
Frontotemporal Dementia
Frontotemporal Lobar Degeneration
Molecular Biology*
Neurofibrillary Tangles
Parkinsonian Disorders
Pathology
Pick Disease of the Brain
Plaque, Amyloid
Prednisolone
Supranuclear Palsy, Progressive
tau Proteins*
Tauopathies
Amyloid
Prednisolone
tau Proteins