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Targeted Downregulation of kdm4a Ameliorates Tau-engendered Defects in Drosophila melanogaster

Park SY, Seo J, Chun YS

BACKGROUND: Tauopathies, a class of neurodegenerative diseases that includes Alzheimer's disease (AD), are characterized by the deposition of neurofibrillary tangles composed of hyperphosphorylated tau protein in the human brain. As...
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No Evidence of a Contribution of the Vestibular System to Frequent Falls in Progressive Supranuclear Palsy

Goldschagg N, Bremova-Ertl T, Bardins S, Dinca N, Feil K, Krafczyk S, Lorenzl S, Strupp M

BACKGROUND AND PURPOSE: Conflicting results about vestibular function in progressive supranuclear palsy (PSP) prompted a systematic examination of the semicircular canal function, otolith function, and postural stability. METHODS: Sixteen patients with...
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Gait Ignition Failure in JNPL3 Human Tau-mutant Mice

Jang H, Ryu JH, Shin KM, Seo NY, Kim GH, Huh YH, Pae AN, Lee KJ

Cognitive impairments and motor dysfunction are commonly observed behavioral phenotypes in genetic animal models of neurodegenerative diseases. JNPL3 transgenic mice expressing human P301L-mutant tau display motor disturbances with age- and...
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Primary Age-Related Tauopathy: An Elderly Brain Pathology Frequently Encountered during Autopsy

Kim D, Kim HS, Choi SM, Kim BC, Lee MC, Lee KH, Lee JH

Due to the progressive aging of Korean society and the introduction of brain banks to the Korean medical system, the possibility that pathologists will have access to healthy elderly brains...
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Regulation of Diabetes: a Therapeutic Strategy for Alzheimer's Disease?

Ahn KC, Learman CR, Baker GB, Weaver CL, Chung PS, Kim HG, Song MS

Accumulated evidence suggests that sporadic cases of Alzheimer's disease (AD) make up more than 95% of total AD patients, and diabetes has been implicated as a strong risk factor for...
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Development of tau PET Imaging Ligands and their Utility in Preclinical and Clinical Studies

Choi Y, Ha S, Lee YS, Kim YK, Lee DS, Kim DJ

The pathological features of Alzheimer's disease are senile plaques which are aggregates of β-amyloid peptides and neurofibrillary tangles in the brain. Neurofibrillary tangles are aggregates of hyperphosphorylated tau proteins, and...
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¹⁸F-THK5351 PET Imaging in the Behavioral Variant of Frontotemporal Dementia

Nam G, Jeong HJ, Kang JM, Lee SY, Seo S, Seo HE, Park KH, Yeon BK, Ido T, Shin DJ, Noh Y

BACKGROUND AND PURPOSE: Behavioral variant frontotemporal dementia (bvFTD) is a subtype of frontotemporal dementia, which has clinical symptoms of progressive personality and behavioral changes with deterioration of social cognition and...
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The role of PI3K/AKT pathway and its therapeutic possibility in Alzheimer's disease

Yu HJ, Koh SH

Alzheimer's disease (AD) is the most common form of dementia. Although uncountable clinical trials have been done to develop the treatment of AD, there are a couple of drugs that...
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Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy

Seo JS, Lee S, Shin JY, Hwang YJ, Cho H, Yoo SK, Kim Y, Lim S, Kim YK, Hwang EM, Kim SH, Kim CH, Hyeon SJ, Yun JY, Kim J, Kim Y, Alvarez VE, Stein TD, Lee J, Kim DJ, Kim JI, Kowall NW, Ryu H, McKee AC

Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disorder that is associated with repetitive head injury and has distinctive neuropathological features that differentiate this disease from other neurodegenerative diseases. Intraneuronal...
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Clinical Approach to Progressive Supranuclear Palsy

Ling H

Sixty years ago, Steele, Richardson and Olszewski designated progressive supranuclear palsy (PSP) as a new clinicopathological entity in their seminal paper. Since then, in addition to the classic Richardson's syndrome...
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Longitudinal Clinical Changes of Non-Fluent/Agrammatic Primary Progressive Aphasia as Tau Spectrum Disorder: A Case Report

Kim JS, Jang JW, Kim SH, Wang MJ, Park YH, Kim S

BACKGROUND: Tauopathies are a group of diseases caused by the accumulation of hyperphosphorylated tau protein in the central nervous system. Previous studies have revealed that there is considerable overlap in...
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Sleep Disorders in Neurodegenerative Disorders

Seo JG, Park SP, Lee HW

  • KMID: 2334722
  • J Korean Sleep Res Soc.
  • 2014 Jun;11(1):1-4.
Neurodegenerative diseases result from deterioration of neurons which may eventually lead to central nervous system-related dysfunction including sleep disorders. The pathogenesis of these disturbances may be secondary to direct structural...
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Houttuynia cordata Improves Cognitive Deficits in Cholinergic Dysfunction Alzheimer's Disease-Like Models

Huh E, Kim HG, Park H, Kang MS, Lee B, Oh MS

  • KMID: 2170634
  • Biomol Ther.
  • 2014 May;22(3):176-183.
Cognitive impairment is a result of dementia of diverse causes, such as cholinergic dysfunction and Alzheimer's disease (AD). Houttuynia cordata Thunb. (Saururaceae) has long been used as a traditional herbal...
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Clinical and Pathological Characteristics of Frontotemporal Lobar Degeneration(FTLD) and Molecular Genetics of Tau Protein

Woo SI

  • KMID: 2202778
  • J Korean Soc Biol Psychiatry.
  • 2003 Nov;10(2):97-106.
Criticisms about amyloid cascade hypothesis of Alzheimer's disease(AD) are based on the findings, first, that the degree of dementia does not correlate with the number of plaques, and second, that...
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