- The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity
-
Lee IK
- KMID: 2280687
- Diabetes Metab J.
- 2014 Jun;38(3):181-186.
- doi: 10.4093/dmj.2014.38.3.181
The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient... -
- CITED
-
- Close
- SHARE
-
- Close
- Inhibition of Sarcoplasmic Reticulum Ca2+ Uptake by Pyruvate and Fatty Acid in H9c2 Cardiomyocytes: Implications for Diabetic Cardiomyopathy
-
Lee EH, Lee HK, Kim HW, Kim YH
- KMID: 1600069
- Korean J Physiol Pharmacol.
- 2005 Aug;9(4):195-201.
High extracellular glucose concentration was reported to suppress intracellular Ca2+ clearing through altered sarcoplasmic reticulum (SR) function. In the present study, we attempted to elucidate the effects of pyruvate and... -
- CITED
-
- Close
- SHARE
-
- Close
- Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers
-
Jeoung NH
- KMID: 2281531
- Diabetes Metab J.
- 2015 Jun;39(3):188-197.
- doi: 10.4093/dmj.2015.39.3.188
Impaired glucose homeostasis is one of the risk factors for causing metabolic diseases including obesity, type 2 diabetes, and cancers. In glucose metabolism, pyruvate dehydrogenase complex (PDC) mediates a major... -
- CITED
-
- Close
- SHARE
-
- Close
- Anesthetic experience in a pediatric patient with pyruvate dehydrogenase complex (PDHC) deficiency: A case report
-
Ro J, Kim EJ, Lee JH, Lee SG, Ban JS, Min BW
- KMID: 2243008
- Korean J Anesthesiol.
- 2008 Nov;55(5):629-633.
- doi: 10.4097/kjae.2008.55.5.629
Mitochondrial dysfunction represents a biochemically and clinically diverse group of conditions that can affect any organs with high energy requirement such as brain and muscle being particularly vulnerable. Pyruvate dehydrogenase... -
- CITED
-
- Close
- SHARE
-
- Close
- Role of Pyruvate Dehydrogenase Kinase 4 in Regulation of Blood Glucose Levels
-
Jeoung NH, Harris RA
- KMID: 2029884
- Korean Diabetes J.
- 2010 Oct;34(5):274-283.
- doi: 10.4093/kdj.2010.34.5.274
In the well-fed state a relatively high activity of the pyruvate dehydrogenase complex (PDC) reduces blood glucose levels by directing the carbon of pyruvate into the citric acid cycle. In... -
- CITED
-
- Close
- SHARE
-
- Close
- Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases
-
Patel MS, Korotchkina LG
- KMID: 1457529
- Exp Mol Med.
- 2001 Dec;33(4):191-197.
This review summarizes the recent developments on the regulation of human pyruvate dehydrogenase complex (PDC) by site-specific phosphorylation by four kinases. Mutagenic analysis of the three phosphorylation sites of human... -
- CITED
-
- Close
- SHARE
-
- Close
- Red Blood Cell Enzymopathies Causing Hereditary Hemolytic Anemia
-
Hah JO
- KMID: 1441716
- Clin Pediatr Hematol Oncol.
- 2012 Apr;19(1):1-6.
The RBC enzyme deficiencies causing hereditary hemolytic anemia (HHA) can be divided into three groups: those participating in the glycolytic (E-M) pathway; those involved with the maintenance of a high... -
- CITED
-
- Close
- SHARE
-
- Close
- Ethyl Pyruvate Has Anti-Inflammatory and Delayed Myocardial Protective Effects after Regional Ischemia/Reperfusion Injury
-
Jang IS, Park MY, Shin IW, Sohn JT, Lee HK, Chung YK
- KMID: 1779628
- Yonsei Med J.
- 2010 Nov;51(6):838-844.
- doi: 10.3349/ymj.2010.51.6.838
PURPOSE: Ethyl pyruvate has anti-inflammatory properties and protects organs from ischemia/reperfusion (I/R)-induced tissue injury. The aim of this study was to determine whether ethyl pyruvate decreases the inflammatory response after... -
- CITED
-
- Close
- SHARE
-
- Close
- Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism
-
Park S, Jeon JH, Min BK, Ha CM, Thoudam T, Park BY, Lee IK
- KMID: 2418715
- Diabetes Metab J.
- 2018 Aug;42(4):270-281.
- doi: 10.4093/dmj.2018.0101
Mitochondrial dysfunction is a hallmark of metabolic diseases such as obesity, type 2 diabetes mellitus, neurodegenerative diseases, and cancers. Dysfunction occurs in part because of altered regulation of the mitochondrial... -
- CITED
-
- Close
- SHARE
-
- Close
- Influence of 120 kDa Pyruvate:Ferredoxin Oxidoreductase on Pathogenicity of Trichomonas vaginalis
-
Song HO
- KMID: 2374020
- Korean J Parasitol.
- 2016 Feb;54(1):71-74.
- doi: 10.3347/kjp.2016.54.1.71
Trichomonas vaginalis is a flagellate protozoan parasite and commonly infected the lower genital tract in women and men. Iron is a known nutrient for growth of various pathogens, and also... -
- CITED
-
- Close
- SHARE
-
- Close
- A Korean Female Patient with Thiamine-responsive Pyruvate Dehydrogenase Complex Deficiency Due to a Novel Point Mutation (Y161C)in the PDHA1 Gene
-
Lee EH, Ahn MS, Hwang JS, Ryu KH, Kim SJ, Kim SH
- KMID: 1781895
- J Korean Med Sci.
- 2006 Oct;21(5):800-804.
- doi: 10.3346/jkms.2006.21.5.800
Pyruvate dehydrogenase complex (PDHC) deficiency is mostly due to mutations in the X-linked E1alpha subunit gene (PDHA1). Some of the patients with PDHC deficiency showed clinical improvements with thiamine treatment.... -
- CITED
-
- Close
- SHARE
-
- Close
- Hereditary Hemolytic Anemia
-
Hah JO
- KMID: 2064970
- J Korean Med Assoc.
- 2006 Oct;49(10):908-919.
- doi: 10.5124/jkma.2006.49.10.908
The hereditary hemolytic anemia (HHA) can be classified into three types according to the pathogenesis: RBC membrane defects, hemoglobinopathies, and RBC enzymopathies. Clinical characteristics of these three types of HHA... -
- CITED
-
- Close
- SHARE
-
- Close
- RBC Enzyme Analysis
-
Song J
- KMID: 2049286
- Clin Pediatr Hematol Oncol.
- 2013 Apr;20(1):8-12.
Among ~20 RBC enzyme deficiencies causing hereditary hemolytic anemia (HRA), deficiencies involving three RBC enzymes such as glucose-6-phosphatase, pyruvate kinase and pyrimidine 5'-nucleodiase were known to be relatively common. The... -
- CITED
-
- Close
- SHARE
-
- Close
- Transcriptional Regulation of Pyruvate Dehydrogenase Kinase
-
Jeong JY, Jeoung NH, Park KG, Lee IK
- KMID: 2174390
- Diabetes Metab J.
- 2012 Oct;36(5):328-335.
- doi: 10.4093/dmj.2012.36.5.328
The pyruvate dehydrogenase complex (PDC) activity is crucial to maintains blood glucose and ATP levels, which largely depends on the phosphorylation status by pyruvate dehydrogenase kinase (PDK) isoenzymes. Although it... -
- CITED
-
- Close
- SHARE
-
- Close
- Profiling of Proteins Regulated by Venlafaxine during Neural Differentiation of Human Cells
-
Doh MS, Han DM, Oh DH, Kim SH, Choi MR, Chai YG
- KMID: 2316393
- Psychiatry Investig.
- 2015 Jan;12(1):81-91.
- doi: 10.4306/pi.2015.12.1.81
OBJECTIVE: Antidepressants are known to positively influence several factors in patients with depressive disorders, resulting in increased neurogenesis and subsequent relief of depressive disorders. To study the effects of venlafaxine... -
- CITED
-
- Close
- SHARE
-
- Close
- Hemolytic anemia in pediatrics
-
Hah JO
- KMID: 2278471
- Korean J Pediatr.
- 2007 Jun;50(6):511-518.
- doi: 10.3345/kjp.2007.50.6.511
To understand the hemolytic anemia (HA) in children, the diagnostic approach and management of hereditary and acquired HA are described. The hereditary hemolytic anemia (HHA) can be classified according to... -
- CITED
-
- Close
- SHARE
-
- Close
- The Usefulness of a Novel Screening Kit for Colorectal Cancer Using the Immunochromatographic Fecal Tumor M2 Pyruvate Kinase Test
-
Kim YC, Kim JH, Cheung DY, Kim TH, Jun EJ, Oh JW, Kim CW, Chung WC, Kim BW, Kim SS, Kim JI, Park SH, Kim JK
- KMID: 2234071
- Gut Liver.
- 2015 Sep;9(5):641-648.
- doi: 10.5009/gnl13457
BACKGROUND/AIMS: M2 pyruvate kinase (M2-PK) is an enzyme that is produced in undifferentiated and proliferating tissues. This study aims to evaluate the usefulness of the immunochromatographic M2 pyruvate kinase (iM2-PK)... -
- CITED
-
- Close
- SHARE
-
- Close
- The in Vitro Maturation of the Mouse Oocyte
-
Bae IH, Chung SO
- KMID: 687695
- Yonsei Med J.
- 1975 Jun;16(1):18-28.
- doi: 10.3349/ymj.1975.16.1.18
Mouse follicular oocytes, denuded and intact, were cultured in pyruvate salt sol and glutamine salt sol supplemented bovine serum albumin to compare the maturation rate. Glutamine has no effect on... -
- CITED
-
- Close
- SHARE
-
- Close
- Knockdown of the M2 Isoform of Pyruvate Kinase (PKM2) with shRNA Enhances the Effect of Docetaxel in Human NSCLC Cell Lines In Vitro
-
Yuan S, Qiao T, Zhuang X, Chen W, Xing N, Zhang Q
- KMID: 2427147
- Yonsei Med J.
- 2016 Nov;57(6):1312-1323.
- doi: 10.3349/ymj.2016.57.6.1312
PURPOSE: The aim of our study was to explore the relationships between the M2 isoform of pyruvate kinase (PKM2) and the sensitivity of human non-small cell lung cancer (NSCLC) cells... -
- CITED
-
- Close
- SHARE
-
- Close
- Regulation of Muscle Pyruvate Dehydrogenase Complex in Insulin Resistance: Effects of Exercise and Dichloroacetate
-
Constantin-Teodosiu D
- KMID: 1965976
- Diabetes Metab J.
- 2013 Oct;37(5):301-314.
- doi: 10.4093/dmj.2013.37.5.301
Since the mitochondrial pyruvate dehydrogenase complex (PDC) controls the rate of carbohydrate oxidation, impairment of PDC activity mediated by high-fat intake has been advocated as a causative factor for the... -
- CITED
-
- Close
- SHARE
-
- Close
