- Increase of Intracellular Ca2+ Concentration Induced by Lysophosphatidylcholine in Murine Aortic Endothelial Cells
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Zhu MH, Park SJ, Kim HJ, Yang DK, Suh SH, So I, Kim KW
- KMID: 1614997
- Korean J Physiol Pharmacol.
- 2002 Apr;6(2):93-100.
Effects of oxidized low-density lipoprotein (ox-LDL), l-alpha-stearoyl-lysophosphatidylcholine (LPC), on intracellular Ca2+ concentration were examined in mouse endothelial cells by measuring intracellular Ca2+ concentration ([Ca2+]i) with fura 2-AM and reverse transcription-polymerase... -
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- A study on the lipids of Chinese liverfluke, Clonorchis sinensis
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Lee SH, Song CY, Cho BH
- KMID: 1713313
- Korean J Parasitol.
- 1977 Dec;15(2):109-114.
- doi: 10.3347/kjp.1977.15.2.109
The present study was undertaken to observe the quality and quantity of lipids in the adult worms of Chinese liverfluke, Clonorchis sinensis. Lipid extraction was done by the methods of... -
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- Bioactive Lysophosphatidylcholine 16:0 and 18:0 Are Elevated in Lungs of Asthmatic Subjects
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Yoder M, Zhuge Y, Yuan Y, Holian O, Kuo S, van Breemen R, Thomas LL, Lum H
- KMID: 2166937
- Allergy Asthma Immunol Res.
- 2014 Jan;6(1):61-65.
- doi: 10.4168/aair.2014.6.1.61
PURPOSE: Asthma is a chronic inflammatory disease of the airways, and is associated with upregulation of phospholipase A2 (PLA2), the enzyme that hydrolyzes phosphatidylcholine, producing lysophosphatidylcholine (LPC) and free fatty... -
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- Lysophosphatidylcholine Increases Ca2+ Current via Activation of Protein Kinase C in Rabbit Portal Vein Smooth Muscle Cells
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Jung S, Lee Y, Han S, Kim Y, Nam T, Ahn D
- KMID: 2071643
- Korean J Physiol Pharmacol.
- 2008 Feb;12(1):31-35.
- doi: 10.4196/kjpp.2008.12.1.31
Lysophosphatidylcholine (LPC), a metabolite of membrane phospholipids by phospholipase A(2), has been considered responsible for the development of abnormal vascular reactivity during atherosclerosis. Ca2+ influx was shown to be augmented... -
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- Lysophosphatidylcholine suppresses apoptosis and induces neurite outgrowth in PC12 cells through activation of phospholipase D2
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Yun DH, Jeon ES, Sung SM, Ryu SH, Kim JH
- KMID: 1110121
- Exp Mol Med.
- 2006 Aug;38(4):375-384.
Lysophosphatidylcholine (LPC) is a bioactive lipid generated by phospholipase A2-mediated hydrolysis of phosphatidylcholine. In the present study, we demonstrate that LPC stimulates phospholipase D2 (PLD2) activity in rat pheochromocytoma PC12... -
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- Effect of Salicylate on the Monocyte Chemoattractant Protein-1 Expression and Intracellular Reactive Oxygen Species Formation in Human Mesangial Cells
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Chung SJ, Kim CS, Chang JW, Kim SB, Lee SK, Park JS
- KMID: 1610145
- Korean J Nephrol.
- 2003 May;22(3):261-272.
BACKGROUND: Monocyte chemoattractant protein-1 (MCP-1) and reactive oxygen species (ROS) play an important role during glomerular inflammation. We investigated the effect of aspirin metabolite, salicylate on the pro-inflammatory cytokine-induced MCP-1... -
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- Lysophosphatidylcholine Attenuates Endothelium-dependent Relaxation Responses through Inhibition of ACh-induced Endothelial [Ca2+]i Increase
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Kwon SC, Lee YH, Nam T, Ahn DS
- KMID: 1512938
- Korean J Physiol Pharmacol.
- 2006 Feb;10(1):25-30.
Lysophosphatidylcholine (LPC), which accumulates in atherosclerotic arteries, has been reported to inhibit endothelium-dependent relaxation (EDR) in many different species. However, the underlying mechanism of LPC-induced inhibition of EDR is still... -
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- Stimulated Bronchial Epithelial Cells Release Bioactive Lysophosphatidylcholine 16:0, 18:0, and 18:1
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Zhuge Y, Yuan Y, van Breemen R, DeGrand M, Holian O, Yoder M, Lum H
- KMID: 2166940
- Allergy Asthma Immunol Res.
- 2014 Jan;6(1):66-74.
- doi: 10.4168/aair.2014.6.1.66
PURPOSE: In human subjects and animal models with acute and chronic lung injury, the bioactive lysophosphatidylcholine (LPC) is elevated in lung lining fluids. The increased LPC can promote an inflammatory... -
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- Oxidized Low-density Lipoprotein- and Lysophosphatidylcholine-induced Ca2+ Mobilization in Human Endothelial Cells
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Kim MY, Liang GH, Kim JA, Choi SS, Choi S, Suh SH
- KMID: 2285368
- Korean J Physiol Pharmacol.
- 2009 Feb;13(1):27-32.
- doi: 10.4196/kjpp.2009.13.1.27
The effects of oxidized low-density lipoprotein (OxLDL) and its major lipid constituent lysophosphatidylcholine (LPC) on Ca2+ entry were investigated in cultured human umbilical endothelial cells (HUVECs) using fura-2 fluorescence and... -
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- Lysophosphatidylcholine, Oxidized Low-Density Lipoprotein and Cardiovascular Disease in Korean Hemodialysis Patients: Analysis at 5 Years of Follow-up
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Lee YK, Lee DH, Kim JK, Park MJ, Yan JJ, Song DK, Vaziri ND, Noh JW
- KMID: 1429196
- J Korean Med Sci.
- 2013 Feb;28(2):268-273.
- doi: 10.3346/jkms.2013.28.2.268
Although oxidized low-density lipoprotein (LDL) and lysophosphatidylcholine (LPC) have been proposed as important mediators of the atherosclerosis, the long-term contribution to the risk of cardiovascular disease (CVD) in hemodialysis patients... -
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- The Effect of Naringin on the Lysophosphatidylcholine-induced Proliferation of Vascular Smooth Muscle Cells
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Kim SH, Kim IW, Lee HY, Chae IH, Kim MA, Kim HS, Kim CH, Sohn DW, Oh BH, Lee MM, Park YB, Choi YS, Lee YW
- KMID: 1643996
- Korean Circ J.
- 2002 Jan;32(1):61-70.
- doi: 10.4070/kcj.2002.32.1.61
BACKGROUND AND OBJECTIVES: Lysophosphatidylcholine (lysoPC), an atherogenic lysophospholipid, is known to induce the proliferation of vascular smooth muscle cells (VSMCs). Naringin is a flavonoid in grapes and grapefruits and has... -
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- Cytotoxic Effects of Lysophosphatidylcholine on Vascular Smooth Muscle Cells
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Lee DY, Kang YH, Choi DS, Lee YJ, Rhyu MR, Yoon BK
- KMID: 2321326
- J Korean Soc Menopause.
- 2012 Dec;18(3):139-146.
OBJECTIVES: To investigate the cytotoxic effects of lysophosphatidylcholine (lysoPC), an active component of oxidized low-density lipoproteins (LDL), on vascular smooth muscle cells (VSMCs). METHODS: VSMCs were derived from rat aorta. Cell... -
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- Intercellular Lipid Mediators and GPCR Drug Discovery
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Im DS
- KMID: 2170658
- Biomol Ther.
- 2013 Nov;21(6):411-422.
G-protein-coupled receptors (GPCR) are the largest superfamily of receptors responsible for signaling between cells and tissues, and because they play important physiological roles in homeostasis, they are major drug targets.... -
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- Impact of Lysophosphatidylcholine on the Plasminogen Activator System in Cultured Vascular Smooth Muscle Cells
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Yoon BK, Kang YH, Oh WJ, Park K, Lee DY, Choi D, Kim DK, Lee Y, Rhyu MR
- KMID: 2157928
- J Korean Med Sci.
- 2012 Jul;27(7):803-810.
- doi: 10.3346/jkms.2012.27.7.803
The balance between tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1) regulates fibrinolysis. PAI-1 expression increases in atherosclerotic arteries and vascular smooth muscle cells (VSMCs) are one... -
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- Lipidomic analysis of plasma lipids composition changes in septic mice
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Ahn WG, Jung JS, Song DK
- KMID: 2414264
- Korean J Physiol Pharmacol.
- 2018 Jul;22(4):399-408.
- doi: 10.4196/kjpp.2018.22.4.399
A lipidomic study on extensive plasma lipids in bacterial peritonitis (cecal ligation and puncture, CLP)-induced sepsis in mice was done at 24 h post-CLP. The effects of administration of lysophosphatidylcholine... -
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- Association of the vascular endothelial damage and estrogen, progesterone
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Kim MK, Kim JA, Jeon YJ, Park JS, Park MH, Suh SH, Chun SH, Ahn JJ, Kim YJ
- KMID: 1870353
- Korean J Obstet Gynecol.
- 2007 Mar;50(3):429-438.
OBJECTIVE: The aim of this study were to examine the serum level of estradiol, estriol, progesterone, oxidized LDL in preeclamtic patients and to evaluate the protective effects of estrogen and... -
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- Effect of lysophosphatidylcholine on whole cell K+ current in rabbit coronary smooth muscle cells.
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Yi CH, Ha MY, Ahn DS, Kang BS
- KMID: 1858588
- Korean Circ J.
- 2001 Feb;31(2):217-229.
- doi: 10.4070/kcj.2001.31.2.217
BACKGROUND: Impairment of relaxing response and augmentation of contractile response to vasoactive substances have been reported in atherosclerotic arteries. These alterations in vascular reactivity are considered as an underlying mechanism... -
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- Biomarker for Ischemic Stroke Using Metabolome: A Clinician Perspective
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Sidorov E, Sanghera D, Vanamala J
- KMID: 2438648
- J Stroke.
- 2019 Jan;21(1):31-41.
- doi: 10.5853/jos.2018.03454
Finding ischemic stroke biomarker is highly desirable because it can improve diagnosis even before a patient arrives to the hospital. Metabolome is one of new technologies that help to find... -
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- Profiling of Serum Metabolites Using MALDI-TOF and Triple-TOF Mass Spectrometry to Develop a Screen for Ovarian Cancer
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Lee JH, Kim YH, Kim KH, Cho JY, Woo SM, Yoo BC, Kim SC
- KMID: 2417877
- Cancer Res Treat.
- 2018 Jul;50(3):883-893.
- doi: 10.4143/crt.2017.275
PURPOSE: We sought to develop a matrix assisted laser desorption ionization-time of flight (MALDI-TOF)-based, ovarian cancer (OVC), low-mass-ion discriminant equation (LOME) and to evaluate a possible supportive role for triple-TOF... -
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- Influences of Free Fatty Acids on Transmembrane Action Potential and ATP-sensitive Potassium Channel Activity in Rat Myocardium
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Kim JH, Ju JM, Park J, Baik YH, Kook H, Jeong HS, Jeong MH, Cho JG, Park JC, Kang JC
- KMID: 2093795
- Korean Circ J.
- 2000 Dec;30(12):1589-1589.
- doi: 10.4070/kcj.2000.30.12.1589
BACKGROUND: To evaluate the role of free fatty acids on the ischemic myocardium, influences of various free fatty acids upon transmembrane action potential and ATP-sensitive K+(KATP) channel activity were examined... -
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