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Development and trial of vaccines against Brucella

Lalsiamthara J, Lee JH

The search for ideal brucellosis vaccines remains active today. Currently, no licensed human or canine anti-brucellosis vaccines are available. In bovines, the most successful vaccine (S19) is only used in...
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Immunogenicity and Safety of Trivalent Split Influenza Vaccine in Healthy Korean Adults with Low Pre-Existing Antibody Levels: An Open Phase I Trial

Kang K, Han S, Hong T, Jeon S, Paek J, Kang JH, Yim DS

PURPOSE: A phase I clinical trial was conducted to evaluate the immunogenicity and safety of newly developed egg-cultivated trivalent inactivated split influenza vaccine (TIV) in Korea. MATERIALS AND METHODS: The TIV...
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Assessment of the safety and efficacy of low pathogenic avian influenza (H9N2) virus in inactivated oil emulsion vaccine in laying hens

Shin JH, Mo JS, Kim JN, Mo IP, Ha BD

In Korea, several outbreaks of low pathogenic AI (H9N2) viral infections leading to decreased egg production and increased mortality have been reported on commercial farms since 1996, resulting in severe...
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Improved immunogenicity of Newcastle disease virus inactivated vaccine following DNA vaccination using Newcastle disease virus hemagglutinin-neuraminidase and fusion protein genes

Firouzamandi M, Moeini H, Hosseini D, Bejo MH, Omar AR, Mehrbod P, Ideris A

The present study describes the development of DNA vaccines using the hemagglutinin-neuraminidase (HN) and fusion (F) genes from AF2240 Newcastle disease virus strain, namely pIRES/HN, pIRES/F and pIRES-F/HN. Transient expression...
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Reappraisal of the Immunogenicity and Safety of Three Hepatitis A Vaccines in Adolescents

Yoon SH, Kim HW, Ahn JG, Kim IT, Kim JH, Kong KA, Kim KH

Although the overall incidence of hepatitis A in Korea has been decreasing, adolescents remain highly vulnerable to its outbreaks. This study was conducted to compare the immunogenicity and safety of...
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Augmented immune responses in pigs immunized with an inactivated porcine reproductive and respiratory syndrome virus containing the deglycosylated glycoprotein 5 under field conditions

Lee JA, Lee NH, Lee JB, Park SY, Song CS, Choi IS, Lee SW

PURPOSE: Porcine reproductive and respiratory syndrome virus (PRRSV) leads to major economic losses in the swine industry. Vaccination is the most effective method to control the disease by PRRSV. MATERIALS AND...
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Porcine reproductive and respiratory syndrome virus vaccine does not fit in classical vaccinology

Lyoo YS

All vaccines are developed to elicit an effective immune response in vaccinated animals such as innate, humoral and cell mediated response to protect animal health. Quality and intensity of the...
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Protective efficacy of a high-growth reassortant swine H3N2 inactivated vaccine constructed by reverse genetic manipulation

Wen F, Ma JH, Yu H, Yang FR, Huang M, Zhou YJ, Li ZJ, Tong GZ

Novel reassortant H3N2 swine influenza viruses (SwIV) with the matrix gene from the 2009 H1N1 pandemic virus have been isolated in many countries as well as during outbreaks in multiple...
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Antibody Response in Cattle and Guinea Pigs Inoculated with Rabies Vaccines

Yang DK, Jeong WH, Kim HH, Nah JJ, Kim JJ, Choi SS, Kim JT, Song JY

One hundred ninety-five rabies cases in cattle were identified in South Korea since 1993. As most of rabies cases have a relation to rabid Korean raccoon dogs (Nyctereutes procyonoides koreensis),...
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Protection of chickens against infectious bronchitis virus with a multivalent DNA vaccine and boosting with an inactivated vaccine

Yan F, Zhao Y, Hu Y, Qiu J, Lei W, Ji W, Li X, Wu Q, Shi X, Li Z

The protective efficacy of DNA plasmids encoding avian infectious bronchitis virus (IBV) S1, N, or M protein was investigated in chickens. Chickens were inoculated monovalently (with plasmid pVAX1-16S1, pVAX1-16M, or...
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Principles underlying rational design of live attenuated influenza vaccines

Jang YH, Seong BL

Despite recent innovative advances in molecular virology and the developments of vaccines, influenza virus remains a serious burden for human health. Vaccination has been considered a primary countermeasure for prevention...
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Safety and Immunogenicity of a New Trivalent Inactivated Split-virus Influenza Vaccine in Healthy Korean Children: A Randomized, Double-blinded, Active-controlled, Phase III Study

Kang JH, Oh CE, Lee J, Lee SY, Cha SH, Kim DS, Kim HH, Lee JH, Kim JT, Ma SH, Hong YJ, Cheong HJ, Lee HJ

We report results of a randomized, double-blinded, active-controlled, phase III study conducted to evaluate the immunogenicity and safety of a new trivalent inactivated split-virus influenza vaccine (GC501) manufactured by the...
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Molecular Identification of the Vaccine Strain from the Inactivated Rabies Vaccine

Yang DK, Oh YI, Cho SD, Kang HK, Lee KW, Kim YH, Song JY

Since 1994, several different inactivated rabies vaccines have been used to immunize domestic animals such as dogs, cats, and cattle in South Korea. The Korean Veterinary Authority has conducted safety...
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Immunogenicity and Safety of Trivalent Inactivated Influenza Vaccine: A Randomized, Double-Blind, Multi-Center, Phase 3 Clinical Trial in a Vaccine-Limited Country

Song JY, Cheong HJ, Woo HJ, Wie SH, Lee JS, Chung MH, Kim YR, Jung SI, Park KH, Kim TH, Uh ST, Kim WJ

Influenza vaccines are the primary method for controlling influenza and its complications. This study was conducted as a phase 3, randomized, double-blind, controlled, multi-center trial at seven university hospitals to...
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Molecular identification of the vaccine strain from the inactivated oil emulsion H9N2 low pathogenic avian influenza vaccine

Choi JG, Lee YJ, Kim JY, Kim YH, Paek MR, Yang DK, Son SW, Kim JH

In order to control the H9N2 subtype low pathogenic avian influenza (LPAI), an inactivated vaccine has been used in Korea since 2007. The Korean veterinary authority permitted the use of...
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Investigation on the Frequency and Severity of Common Adverse Reactions of Japanese Encephalitis Vaccines

Kim BY, Kim DH, Lee HJ, Jung SK, Li XS, Go UY, Park SK, Hong YJ

  • KMID: 2278923
  • Korean J Pediatr Infect Dis.
  • 2009 Dec;16(2):183-190.
PURPOSE: To evaluate the number and severity of adverse reactions after Japanese Encephalitis (JE) vaccination in children using different vaccines (inactivated vaccine or live attenuated vaccine) and to determine the...
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Epidemiology and clinical features of acute hepatitis A: from the domestic perspective

Jung YK, Kim JH

Acute viral hepatitis A has recently become a major public health problem in Korea, and the incidence of symptomatic hepatitis A is growing rapidly. With improvements in socioeconomic conditions and...
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Protection of chicken against very virulent IBDV provided by in ovo priming with DNA vaccine and boosting with killed vaccine and the adjuvant effects of plasmid-encoded chicken interleukin-2 and interferon-gamma

Park JH, Sung HW, Yoon BI, Kwon HM

The aim of this study was to examine the efficacy of in ovo prime-boost vaccination against infectious bursal disease virus (IBDV) using a DNA vaccine to prime in ovo followed...
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Protective efficacy of commercial inactivated Newcastle disease virus vaccines in chickens against a recent Korean epizootic strain

Jeon WJ, Lee EK, Lee YJ, Jeong OM, Kim YJ, Kwon JH, Choi KS

Despite the intensive vaccination policy that has been put in place to control Newcastle disease virus (NDV), the recent emergence of NDV genotype VII strains in Korea has led to...
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Current Status and Vaccine Indication for Hepatitis A Virus Infection in Korea

Jeong SH

  • KMID: 1767537
  • Korean J Gastroenterol.
  • 2008 Jun;51(6):331-337.
One of the major cause of recent acute viral hepatitis in Korean adults is hepatitis A virus (HAV) infection. Most of hepatitis A cases are young adults in their twenties...
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